PD180970
- Product Name
- PD180970
- CAS No.
- 287204-45-9
- Chemical Name
- PD180970
- Synonyms
- PD 180970;PD 180790;PF-1515965;PD-180970,PD180970;6-(2,6-dichlorophenyl)-2-(4-fluoro-3-methylanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one;6-(2,6-DICHLORO-PHENYL)-2-(4-FLUORO-3-METHYL-PHENYLAMINO)-8-METHYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE;6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one;PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, 6-(2,6-DICHLOROPHENYL)-2-[(4-FLUORO-3-METHYLPHENYL)AMINO]-8-METHYL-
- CBNumber
- CB82454085
- Molecular Formula
- C21H15Cl2FN4O
- Formula Weight
- 429.27
- MOL File
- 287204-45-9.mol
PD180970 Property
- Boiling point:
- 590.6±60.0 °C(Predicted)
- Density
- 1.449±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- pka
- 3.02±0.20(Predicted)
- form
- A solid
- color
- yellow
N-Bromosuccinimide Price
- Product number
- PZ0142
- Product name
- PD-180970
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- PZ0142
- Product name
- PD-180970
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $613
- Updated
- 2024/03/01
- Product number
- 462101
- Product name
- PD 180970
- Packaging
- 5mg
- Price
- $382
- Updated
- 2021/12/16
- Product number
- P217825
- Product name
- PD180970
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 2636BB
- Product name
- 6-(2,6-Dichlorophenyl)-2-[(4-Fluoro-3-Methylphenyl)amino]-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One
- Packaging
- 1mg
- Price
- $133
- Updated
- 2021/12/16
PD180970 Chemical Properties,Usage,Production
Uses
PD 180970 is an ATP-competitive inhibitor of p210 tyrosine kinase which selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells.
Enzyme inhibitor
This pyridopyrimidine (FWfree-base = 429.28 g/mol) inhibits Bcr-Abl proteintyrosine kinase and induces apoptosis of K562 leukemic cells. In vitro, PD180970 potently inhibited p210Bcr-Abl autophosphorylation (IC50 = 5 nM) as well as the kinase activity of purified Abl tyrosine kinase (IC50 = 2.2 nM). Incubation of K562 cells with PD180970 resulted in cell death, with results of nuclear staining, apoptotic-specific poly(ADP-ribose) polymerase cleavage, and annexin V binding assays confirming as much. Significantly, PD180970 is without effect on the growth and viability of p210Bcr-Ablnegative HL60 human leukemic cells. Such findings demonstrate that PD180970 is among the most potent known inhibitors of the p210Bcr-Abl tyrosine kinase and that it is a promising candidate as a novel therapeutic agent for Bcr-Abl-positive leukemia
PD180970 Preparation Products And Raw materials
Raw materials
Preparation Products
PD180970 Suppliers
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- 888-539-0666
- Fax
- 888-539-0666
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- Country
- United States
- ProdList
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- +1-781-999-5354 +1-00000000000
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- Country
- United States
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- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
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