(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE

Product Name: (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
CAS No.: 187665-65-2
Chemical Name: (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
Synonyms: PNU 142633;PNU142633,PNU 142633;(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE;1H-2-Benzopyran-6-carboxamide, 1-[2-[4-[4-(aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-, (1S)-
CBNumber: CB82454328
Molecular Formula: C24H30N4O3
Formula Weight: 422.52
MOL File: 187665-65-2.mol

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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE Property

Boiling point:: 652.5±55.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Soluble to 100 mM in DMSO
form: Powder
pka: 15.27±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1985
Product name: PNU142633
Purity: ≥98%(HPLC)
Packaging: 10
Price: $261
Updated: 2021/12/16

Usbiological

Product number: 256292
Product name: PNU 142633
Packaging: 10mg
Price: $516
Updated: 2021/12/16

TRC

Product number: P653455
Product name: PNU142633
Packaging: 1mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0024590
Product name: PNU-142633
Purity: >98.0%
Packaging: 10mg
Price: $965
Updated: 2021/12/16

ApexBio Technology

Product number: B6906
Product name: PNU142633
Packaging: 10mg
Price: $385
Updated: 2021/12/16

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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE Chemical Properties,Usage,Production

Uses

PNU 142633 is a high affinity SR-1D agonist.

Biological Activity

Very selective, high affinity 5-HT 1D receptor agonist (K i values are 6 and > 18000 nM at human 5-HT 1D and 5-HT 1B receptors respectively). Inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo .

in vivo

PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation. And PNU-142633 fails to alter resistance in these vascular beds^[1].

Animal Model:	Male Hartley guinea pigs (250-300 g) stimulated with bipolar electrode^[1]
Dosage:	0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg
Administration:	Intravenous injection
Result:	Significantly reduced extravasation at the 0.1 and 0.3 mg/kg doses, but was without effect at the 0.03 and 1.0 mg/kg doses.

IC 50

5-HT_1D Receptor: 6 nM (Ki)

storage

Store at +4°C

(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE Suppliers

CHINA 21 United Kingdom 1 United States 6 Global 28

3B Pharmachem (Wuhan) International Co.,Ltd.

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EMMX Biotechnology LLC

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Jinan ponder chemical co. LTD

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Energy Chemical

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Shanghai Universal Biotech Co.,Ltd

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TargetMol Chemicals Inc.

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R&D Systems, Inc

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187665-65-2, (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDERelated Search:

(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE

PNU 142633

PNU142633,PNU 142633

1H-2-Benzopyran-6-carboxamide, 1-[2-[4-[4-(aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-, (1S)-

187665-65-2