8-CHLORO-3-IODOQUINOLINE

Product Name: 8-CHLORO-3-IODOQUINOLINE
CAS No.: 847727-21-3
Chemical Name: 8-CHLORO-3-IODOQUINOLINE
Synonyms: 8-CHLORO-3-IODOQUINOLINE;Quinoline, 8-chloro-3-iodo-
CBNumber: CB82455567
Molecular Formula: C9H5ClIN
Formula Weight: 289.5
MOL File: 847727-21-3.mol

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8-CHLORO-3-IODOQUINOLINE Property

storage temp.: 2-8°C(protect from light)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0361532
Product name: 8-CHLORO-3-IODOQUINOLINE
Purity: 95.00%
Packaging: 5MG
Price: $501.93
Updated: 2021/12/16

Matrix Scientific

Product number: 116092
Product name: 8-Chloro-3-iodoquinoline
Purity: >97%
Packaging: 500mg
Price: $676
Updated: 2021/12/16

AK Scientific

Product number: 9427BB
Product name: 8-Chloro-3-iodoquinoline
Packaging: 250mg
Price: $104
Updated: 2021/12/16

Ambeed

Product number: A117544
Product name: 8-Chloro-3-iodoquinoline
Purity: 97%
Packaging: 5g
Price: $293
Updated: 2021/12/16

Alichem

Product number: 847727213
Product name: 8-Chloro-3-iodoquinoline
Packaging: 1g
Price: $400.05
Updated: 2021/12/16

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8-CHLORO-3-IODOQUINOLINE Chemical Properties,Usage,Production

Synthesis

611-33-6

847727-21-3

8-Chloro-3-iodoquinoline (D1) was synthesized as follows: under argon protection, N-iodosuccinimide (67.9 g, 0.30 mmol) was added batchwise to a stirred solution of 8-chloroquinoline (49 g, 0.30 mmol) in acetic acid (300 mL). The reaction mixture was heated to 70 °C and kept for 18 hours. After completion of the reaction, the mixture was concentrated under vacuum. The residue was dissolved in dichloromethane (600 mL) and washed sequentially with 10% aqueous sodium thiosulfate (2 x 300 mL) and 10% aqueous sodium bicarbonate (2 x 300 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated in vacuum to obtain the crude product. The crude product was recrystallized with ethyl acetate to give the title compound (D1) as a yellow solid (42 g, 0.145 mol, 48% yield). The recrystallized residue was further purified by silica gel column chromatography using a gradient elution with toluene/acetone to give the second product (18 g, 69% total yield).

References

[1] Organic Letters, 2015, vol. 17, # 18, p. 4408 - 4411
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3884 - 3890
[3] Patent: WO2005/21530, 2005, A1. Location in patent: Page/Page column 12
[4] Patent: WO2005/30724, 2005, A1. Location in patent: Page/Page column 10-11
[5] Patent: WO2007/39219, 2007, A1. Location in patent: Page/Page column 29-30

8-CHLORO-3-IODOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-CHLORO-3-IODOQUINOLINE Suppliers

China 29 India 1 United States 4 Global 34

Chongqing Kangheyuecheng Pharmaceutical Technology Co., Ltd.

Tel: 023-61183015; 13271886913
Email: kangheyuecheng@163.com
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Shanghai YuanYe Biotechnology Co., Ltd.

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Amadis Chemical Company Limited

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MQ (shanghai) Pharmaceuticals Co., Ltd.

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Aikon International Limited

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Shanghai Chenghe Medical Technology Co. Ltd.

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Email: 18601603956@163.com
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
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Wuhan chuang he chemical co. LTD

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Qi Qi hang Biotechnology Co., Ltd.

Tel: 18151111370
Email: 1046215251@qq.com
Country: China
ProdList: 5999
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847727-21-3, 8-CHLORO-3-IODOQUINOLINERelated Search:

8-CHLORO-3-IODOQUINOLINE

Quinoline, 8-chloro-3-iodo-

847727-21-3