2-FLUORO-3-HYDROXYBENZALDEHYDE
- Product Name
- 2-FLUORO-3-HYDROXYBENZALDEHYDE
- CAS No.
- 103438-86-4
- Chemical Name
- 2-FLUORO-3-HYDROXYBENZALDEHYDE
- Synonyms
- 3-Hydroxy-2-fluorobenzaldehyde;2-FLUORO-3-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-3-hydroxy-;2-Fluoro-3-hydroxybenzaldehyde 98%
- CBNumber
- CB82456014
- Molecular Formula
- C7H5FO2
- Formula Weight
- 140.11
- MOL File
- 103438-86-4.mol
2-FLUORO-3-HYDROXYBENZALDEHYDE Property
- Melting point:
- 112-113℃
- Boiling point:
- 222.4±20.0 °C(Predicted)
- Density
- 1.350±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.99±0.10(Predicted)
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F595198
- Product name
- 2-Fluoro-3-hydroxybenzaldehyde
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- F595198
- Product name
- 2-Fluoro-3-hydroxybenzaldehyde
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- PC448018
- Product name
- 2-Fluoro-3-hydroxybenzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $142
- Updated
- 2021/12/16
- Product number
- 2615-3-Z8
- Product name
- 2-Fluoro-3-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
- Product number
- Z6665
- Product name
- 2-Fluoro-3-hydroxybenzaldehyde
- Packaging
- 5g
- Price
- $416
- Updated
- 2021/12/16
2-FLUORO-3-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production
Synthesis Reference(s)
Synthesis, p. 710, 1988 DOI: 10.1055/s-1988-27681
Synthesis
103438-88-6
103438-86-4
General steps for the synthesis of 2-fluoro-3-hydroxybenzaldehyde from 2-fluoro-3-methoxybenzaldehyde: Step 1: Synthesis of 2-fluoro-3-hydroxybenzaldehyde. BBr3 (4 mL, 4 mmol, 1.0 M solution in heptane) was slowly added dropwise to a dichloromethane solution of 2-fluoro-3-methoxybenzaldehyde at -78 °C. The reaction mixture was stirred at -78 °C for 1 hour, followed by a slow warming to 0 °C and continued stirring for 2 hours. The reaction mixture was poured into water and extracted with ethyl acetate (3 x 10 mL). The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure and the residue was purified by silica gel column chromatography with the eluent being a 0-20% ethyl acetate-hexane solvent mixture to afford the target product 2-fluoro-3-hydroxybenzaldehyde (158 mg, 28% yield) as a white solid. MS data: MS m/z 141 [M + H]+.
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 10, p. 1982 - 1988
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4584 - 4597
[3] Patent: WO2005/82890, 2005, A1. Location in patent: Page/Page column 70
[4] Patent: WO2008/51494, 2008, A1. Location in patent: Page/Page column 115
[5] Patent: WO2013/61052, 2013, A1. Location in patent: Page/Page column 65
2-FLUORO-3-HYDROXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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