2-Pyridinamine, 5-bromo-4-chloro-

Uses

Product Name: 2-Pyridinamine, 5-bromo-4-chloro-
CAS No.: 942947-94-6
Chemical Name: 2-Pyridinamine, 5-bromo-4-chloro-
Synonyms: 2-Hydroxy-3-Methoxybenzoic;5-BroMo-4-chloro-2-aMinopyri;5-Bromo-4-chloro-2-aminop...;5-bromo-4-chloro-2-Pyridinamine;5-bromo-4-chloropyridin-2-amine;5-BroMo-4-chloro-2-aMinopyridine;2-Amino-4-chloro-5-bromopyridine;2-Amino-5-bromo-4-chloroPyridine;2-Pyridinamine, 5-bromo-4-chloro-;5-BroMo-4-chloro-pyridin-2-ylaMine
CBNumber: CB82456690
Molecular Formula: C5H4BrClN2
Formula Weight: 207.46
MOL File: 942947-94-6.mol

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2-Pyridinamine, 5-bromo-4-chloro- Property

Boiling point:: 271.6±35.0 °C(Predicted)
Density: 1.834±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.61±0.24(Predicted)
form: powder
color: Faint beige
InChI: InChI=1S/C5H4BrClN2/c6-3-2-9-5(8)1-4(3)7/h1-2H,(H2,8,9)
InChIKey: DDOFUMWLNSICHU-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(Br)C(Cl)=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B678823
Product name: 5-Bromo-4-chloropyridin-2-amine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B678823
Product name: 5-Bromo-4-chloropyridin-2-amine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR19535
Product name: 2-Amino-5-bromo-4-chloropyridine
Purity: 97%
Packaging: 1g
Price: $22
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-D-14
Product name: 5-Bromo-4-chloropyridin-2-amine
Purity: 97%
Packaging: 1g
Price: $24
Updated: 2021/12/16

ChemScene

Product number: CS-W009193
Product name: 2-Amino-5-bromo-4-chloropyridine
Purity: 99.12%
Packaging: 5g
Price: $39
Updated: 2021/12/16

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2-Pyridinamine, 5-bromo-4-chloro- Chemical Properties,Usage,Production

Uses

2-Amino-4-chloro-5-bromopyridine can be used to synthesize 2,4-dichloro-5-bromopyridine. 2,4-Dichloro-5-bromopyridine is an important biopharmaceutical intermediate widely used in the synthesis of various drugs. Its small molecular weight and unique structure allow for the derivation of numerous downstream products, giving it a wide range of applications.

Synthesis

19798-80-2

942947-94-6

The general procedure for the synthesis of 2-amino-4-chloro-5-bromopyridine from 2-amino-4-chloropyridine was as follows: 4-chloropyridin-2-amine (8 g, 62.2 mmol) was dissolved in acetonitrile (600 mL) at room temperature, and N-bromosuccinimide (NBS, 11.08 g, 62.2 mmol) was added in batches under stirring. The reaction mixture was stirred continuously for 14 hours at room temperature. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was redissolved in a solvent mixture of ethyl acetate and water. The organic phase was extracted with ethyl acetate (3 x 50 mL) and the combined organic layers were washed sequentially with water (100 mL) and brine (100 mL) and dried over anhydrous sodium sulfate. Concentration of the organic phase under reduced pressure afforded 5-bromo-4-chloropyridin-2-amine as a yellow solid (13 g, 99% yield), which could be used for subsequent reactions without further purification. The product was confirmed by LC-MS (ESI), m/z 207.0 [(M + H)+, calculated value 206.9 for C5H5BrClN2]; LC/MS retention time (Method B): tR = 0.8 min; 1H NMR (400 MHz, CDCl3) δ 8.17 (s, 1H), 6.63 (s, 1H), 4.59 (s, 2H) .

References

[1] Patent: WO2015/38112, 2015, A1. Location in patent: Page/Page column 92; 93
[2] Patent: JP2015/528018, 2015, A. Location in patent: Paragraph 0207
[3] Patent: WO2018/68283, 2018, A1. Location in patent: Paragraph 00263
[4] Patent: WO2015/157360, 2015, A1. Location in patent: Page/Page column 39-40
[5] Patent: WO2014/63778, 2014, A1. Location in patent: Page/Page column 22; 23

2-Pyridinamine, 5-bromo-4-chloro- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyridinamine, 5-bromo-4-chloro- Suppliers

China 193 China Hong Kong 1 India 15 United Kingdom 2 United States 12 Global 223

Carbosynth

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Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Apollo Scientific Ltd.

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Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

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View Lastest Price from 2-Pyridinamine, 5-bromo-4-chloro- manufacturers

Dideu Industries Group Limited

Product: 2-Pyridinamine, 5-bromo-4-chloro- 942947-94-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Hydroxy-3-Methoxybenzoic acid 942947-94-6
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

Career Henan Chemical Co

Product: 2-Pyridinamine, 5-bromo-4-chloro- 942947-94-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

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2-Pyridinamine, 5-bromo-4-chloro- ISO 9001：2015 REACH

2-AMINO -5-BROMO-4-CHIOROPYRIDINE942947-94-6

942947-94-6

C5H4N2ClBr

Amino-pyridine series