4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
- Product Name
- 4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
- CAS No.
- 111661-47-3
- Chemical Name
- 4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
- Synonyms
- 4-Methyl-1,2,3,4-tetrahydroisoquinoline HCl;4-Methyl-1,2,3,4-tetrahydroisoquinoline HCl salt;1,2,3,4-tetrahydro-4-methylisoquinoline hydrochloride;4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
- CBNumber
- CB82456852
- Molecular Formula
- C10H14ClN
- Formula Weight
- 183.68
- MOL File
- 111661-47-3.mol
4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T295635
- Product name
- 1,2,3,4-Tetrahydro-4-methylisoquinolineHydrochloride
- Packaging
- 500mg
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 3H33-5-0F
- Product name
- 4-Methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $888
- Updated
- 2021/12/16
- Product number
- Z3889
- Product name
- 4-Methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride
- Packaging
- 5g
- Price
- $1152
- Updated
- 2021/12/16
- Product number
- P000107528
- Product name
- 4-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- Z3889
- Product name
- 4-Methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride
- Packaging
- 250mg
- Price
- $161
- Updated
- 2021/12/16
4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
1,2,3,4-Tetrahydro-4-methylisoquinoline Hydrochloride is a potent inhibitor of phenylethanolamine N-methyltransferase, an enzyme that catalyzes the formation of epinephrine.
Synthesis
1196-39-0
111661-47-3
General procedure for the synthesis of 4-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride from 4-methylisoquinoline: 0.50 g (3.5 mmol) of 4-methylisoquinoline was dissolved in 50 mL of methanol under a hydrogen atmosphere, and the hydrogenation reaction was carried out with the addition of 50 mg of dichloromethane and 3.5 mL of aqueous 1 M hydrochloric acid. Upon completion of the reaction, the catalyst was removed by diafiltration followed by evaporation of the reaction mixture. A mixture containing the starting material and the product was obtained, which could be used directly in the next step of the reaction without further purification. The yield was 0.60 g, which represents 94% of the theoretical yield.ESI-MS detection showed: m/z = 148 ([M + H]+).
References
[1] Patent: US2011/195954, 2011, A1. Location in patent: Page/Page column 104-105
4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Suppliers
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