METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE
- Product Name
- METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE
- CAS No.
- 882679-40-5
- Chemical Name
- METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE
- Synonyms
- Methyl4-methyl-3-(4,4,5,5-tetramethyl-;Methyl 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan;5-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester;2-Methyl-5-(methoxycarbonyl)benzeneboronic acid pinacol ester;Methyl4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl;5-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester, 95%,;METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE;(3-hydroxy-2,3-dimethylbutan-2-yl)oxy-(5-methoxycarbonyl-2-methylphenyl)borinic acid;Benzoic acid, 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester
- CBNumber
- CB82457248
- Molecular Formula
- C15H21BO4
- Formula Weight
- 276.14
- MOL File
- 882679-40-5.mol
METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE Property
- Boiling point:
- 383.1±35.0 °C(Predicted)
- Density
- 1.07±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- form
- solid
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- BML00283
- Product name
- 5-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $475
- Updated
- 2025/07/31
- Product number
- M329258
- Product name
- 5-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M329258
- Product name
- 5-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- M329258
- Product name
- 5-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 283525
- Product name
- 5-Methoxycarbonyl-2-Methylphenylboronic acid pinacol ester
- Packaging
- 250mg
- Price
- $422
- Updated
- 2021/12/16
METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE Chemical Properties,Usage,Production
Synthesis
104901-43-1
73183-34-3
882679-40-5
General procedure for the synthesis of methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate from methyl 3-bromo-4-methylbenzoate and pinacol ester of biboronic acid: Methyl 3-bromo-4-methylbenzoate (3 mL, 19.2 mmol) was dissolved in 1,4-dioxane (96 mL), bis(pinacolato ) diboron (7.31 g, 28.2 mmol) and potassium acetate (5.65 g, 57.6 mmol) were added. Subsequently, Pd(dppf)Cl2 (2.8 g, 3.84 mmol) was added to the reaction system. The resulting mixture was stirred at 90 °C for 16 h under argon protection. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the addition of water. The reaction mixture was extracted with ethyl acetate (EtOAc), the organic layers were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure and purified by silica gel column chromatography to afford the target product methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (off-white solid, 4.46 g, 84% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.40 (d, 1H), 7.97 (dd, 1H), 7.23 (d, 1H), 3.94-3.87 (m, 3H), 2.58 (s, 3H), 1.35 (d, 12H).
References
[1] Chemical Communications, 2012, vol. 48, # 34, p. 4115 - 4117
[2] Patent: EP2963027, 2016, A1. Location in patent: Paragraph 0470; 0471; 0472
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 4869 - 4881
METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE manufacturers
- Product
- METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 882679-40-5
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20