ChemicalBook > CAS DataBase List > 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE

2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE

Uses

Product Name: 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE
CAS No.: 766545-20-4
Chemical Name: 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE
Synonyms: 2-chloro-5;8-tetrahydro-1;6-naphthyridine hydrochloride;2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HCL;2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-PHTHYRIDINE HYDROCHLORIDE;1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride;2-chloro-5,6,7,8-tetrahydro-1,6-Naphthyridine hydrochloride (1:1);1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride (1:1)
CBNumber: CB82457662
Molecular Formula: C8H10Cl2N2
Formula Weight: 205.08
MOL File: 766545-20-4.mol

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2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C351325
Product name: 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridineHydrochloride
Packaging: 1g
Price: $130
Updated: 2021/12/16

Usbiological

Product number: 269796
Product name: 2-Chloro-5-
Packaging: 2g
Price: $333
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: L14619
Product name: 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridinehydrochloride
Purity: 97%
Packaging: 1g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144167
Product name: 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144167
Product name: 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
Packaging: 1g
Price: $95
Updated: 2021/12/16

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2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

1,6-Naphthidine is one of the most widely studied diazanaphthalene compounds. It is a heterocyclic system composed of two aromatic fused rings containing nitrogen heteroatoms, possessing a unique rigid planar structure that exhibits excellent photophysical and photochemical properties. Therefore, it has wide applications in organic light-emitting materials, optoelectronic devices, fluorescent chemical sensors, organic molecular catalysis, and coordination chemistry. With the deepening research on 1,6-naphthidine, derivatives formed by introducing various groups onto the 1,6-naphthidine ring can interact with small biological molecules or metal ions and possess controllable photophysical properties. In particular, some 1,6-naphthidine derivatives exhibit good physiological activity and have been clinically applied in the treatment of certain diseases.

Synthesis

210539-04-1

766545-20-4

The general procedure for the synthesis of 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride from 6-benzyl-2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine was as follows: 6-benzyl-2-chloro-7,8-dihydro-5H-1,6-diazanaphthalene (2.70 g, 10.43 mmol, 1.00 eq.) was dissolved in ethylene chloride (50.00 mL) in dichloroethane (50.00 mL) and 1-chloroethyl carbonyl chloride (2.24 g, 15.65 mmol, 1.50 eq.) was added. The reaction was carried out at 15 °C under nitrogen protection. The reaction mixture was warmed up to 85 °C and the reaction was stirred for 12 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure. Methanol (50.00 mL) was added to the residue, heated to 80 °C and stirred for 2 hours. The reaction mixture was cooled and filtered, the filter cake was collected and dried to afford 2-chloro-5,6,7,8-tetrahydro-1,6-diazanaphthalene hydrochloride (2.00 g, 9.75 mmol, 93.50% yield) as a white solid. The resulting product was used directly in the next reaction without further purification.

References

[1] Patent: EP3252059, 2017, A1. Location in patent: Paragraph 0118; 0335-0337
[2] Patent: CN106467537, 2017, A. Location in patent: Paragraph 0151; 0152; 0161; 0162
[3] Patent: CN106467538, 2017, A. Location in patent: Paragraph 0181; 0190; 0191

2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE 766545-20-4
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

Career Henan Chemical Co

Product: 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE 766545-20-4
Price: US $1.00/g
Min. Order: 100g
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-23

766545-20-4, 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDERelated Search:

5,6,7,8-TETRAHYDROISOQUINOLINE Nalidixic acid Tetrahydrofurfuryl chloride

2-chloro-5

6-naphthyridine hydrochloride

8-tetrahydro-1

2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HCL

2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-PHTHYRIDINE HYDROCHLORIDE

1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride

1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride (1:1)

2-chloro-5,6,7,8-tetrahydro-1,6-Naphthyridine hydrochloride (1:1)

766545-20-4

C8H9ClN2ClH

Heterocycle-Pyridine series