4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER

Product Name: 4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER
CAS No.: 683242-93-5
Chemical Name: 4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER
Synonyms: -1-cyclohexen-1-yl]-1,3,2-dioxaborolane;4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl);4-(TrifluoroMethyl)cyclohex-1-enylboronic acid pinacol ester;4-(Trifluoromethyl)-1-cyclohexen-1-boronic acid pinacol ester;4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER;4-Trifluoromethyl-1-cyclohexen-1-ylboronic acid pinacol ester;4-(Trifluoromethyl)-1-cyclohexene-1-boronic Acid Pinacol Ester;4,4,5,5-tetramethyl-2-[4-(trifluoromethyl)cyclohexen-1-yl]-1,3,2-dioxaborolane;4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)cyclohex-1-en-1-yl]-1,3,2-dioxaborolane;4,4,5,5-TetraMethyl-2-[4-(trifluoroMethyl)-1-cyclohexen-1-yl]-1,3,2-dioxaborolane
CBNumber: CB82458689
Molecular Formula: C13H20BF3O2
Formula Weight: 276.1
MOL File: 683242-93-5.mol

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4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER Property

Boiling point:: 243℃
Density: 1.10
Flash point:: 101℃
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: solid
color: White to off-white

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BOR0006765
Product name: 4,4,5,5-TETRAMETHYL-2-[4-(TRIFLUOROMETHYL)-1-CYCLOHEXEN-1-YL]-1,3,2-DIOXABOROLANE
Purity: 95.00%
Packaging: 1G
Price: $321.52
Updated: 2021/12/16

Matrix Scientific

Product number: 094575
Product name: 4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)-1-cyclohexen-1-yl]-1,3,2-dioxaborolane
Purity: 95+%
Packaging: 250mg
Price: $908
Updated: 2021/12/16

Matrix Scientific

Product number: 094575
Product name: 4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)-1-cyclohexen-1-yl]-1,3,2-dioxaborolane
Purity: 95+%
Packaging: 1g
Price: $2016
Updated: 2021/12/16

Chemenu

Product number: CM135527
Product name: 4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)-1-cyclohexen-1-yl]-1,3,2-dioxaborolane
Purity: 98%
Packaging: 100mg
Price: $96
Updated: 2021/12/16

Ambeed

Product number: A295226
Product name: 4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)-1-cyclohexen-1-yl]-1,3,2-dioxaborolane
Purity: 98%
Packaging: 100mg
Price: $113
Updated: 2021/12/16

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4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Synthesis

865869-25-6

73183-34-3

683242-93-5

Using 4-(trifluoromethyl)cyclohex-1-allyl trifluoromethanesulfonate (2.24 g, 7.50 mmol, 1.00 eq.) and pinacol bis(boronic acid) ester (2.86 g, 11.26 mmol, 1.50 eq.) as raw materials, under nitrogen protection, Pd(dppf)Cl2 (160 mg, 0.22 mmol, 0.03 eq.), dppf ( 125 mg, 0.23 mmol, 0.03 equiv) and KOAc (2.2 g, 22.42 mmol, 2.99 equiv) were dissolved in dioxane (50 mL). The reaction mixture was stirred at 80 °C for 12 hours. After completion of the reaction, the mixture was concentrated in vacuum. The residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1/20) as eluent to afford 4-(trifluoromethyl)-1-cyclohexene-1-boronic acid pinacol ester (1 g, 48% yield) as a white solid.LCMS [M + H]+ 277. 1H NMR (300 MHz, CDCl3) δ 6.53 (s, 1H), 2.37- 1.98 (m, 7H), 1.26 (s, 12H).

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3719 - 3742
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3528 - 3539
[3] Patent: WO2016/128529, 2016, A1. Location in patent: Paragraph 0828; 0831; 0832
[4] Patent: US2005/182067, 2005, A1. Location in patent: Page/Page column 28-29
[5] Patent: WO2014/49047, 2014, A1. Location in patent: Page/Page column 114; 115; 116

4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER Suppliers

China 69 India 2 United States 8 Global 79

Accela ChemBio Inc.

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Matrix Scientific

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View Lastest Price from 4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER manufacturers

Shanghai Yongzeng Technology Co.,Ltd

Product: 4-(Trifluoromethyl)-1-cyclohexene-1-boronic acid Pinacol Ester 683242-93-5
Price: US $0.00/gm
Min. Order: 100gm
Purity: 99%min
Supply Ability: 100kgs
Release date: 2024-09-06

Career Henan Chemical Co

Product: 4-(Trifluoromethyl)cyclohex-1-enylboronic acid pinacol ester 683242-93-5
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-02

683242-93-5, 4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTERRelated Search:

4-TRIFLUOROMETHYLCYCLOHEX-1-ENYL-1-BORONIC ACID PINACOL ESTER

4-(Trifluoromethyl)-1-cyclohexen-1-boronic acid pinacol ester

1,3,2-Dioxaborolane, 4,4,5,5-tetraMethyl-2-[4-(trifluoroMethyl)-1-cyclohexen-1-yl]-

4,4,5,5-TetraMethyl-2-[4-(trifluoroMethyl)-1-cyclohexen-1-yl]-1,3,2-dioxaborolane

4-(TrifluoroMethyl)cyclohex-1-enylboronic acid pinacol ester

4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)cyclohex-1-en-1-yl]-1,3,2-dioxaborolane

4-Trifluoromethyl-1-cyclohexen-1-ylboronic acid pinacol ester

-1-cyclohexen-1-yl]-1,3,2-dioxaborolane

4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)

4-(Trifluoromethyl)-1-cyclohexene-1-boronic Acid Pinacol Ester

4,4,5,5-tetramethyl-2-[4-(trifluoromethyl)cyclohexen-1-yl]-1,3,2-dioxaborolane

683242-93-5

C13H20BF3O2

C13H22BF3O3