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IVACHTIN

Product Name
IVACHTIN
CAS No.
745046-84-8
Chemical Name
IVACHTIN
Synonyms
IVACHTIN;2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-;2-(4-Methyl-8-(morpholinosulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate;modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced
CBNumber
CB82459565
Molecular Formula
C20H21N3O7S
Formula Weight
447.46
MOL File
745046-84-8.mol
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IVACHTIN Property

Boiling point:
665.0±65.0 °C(Predicted)
Density 
1.459±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
solubility 
Limited solubility, soluble in DMSO or DMF
pka
1.87±0.20(Predicted)
form 
Off-white solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13306
Product name
Caspase-3 Inhibitor VII
Purity
≥98%
Packaging
1mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
13306
Product name
Caspase-3 Inhibitor VII
Purity
≥98%
Packaging
5mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
13306
Product name
Caspase-3 Inhibitor VII
Purity
≥98%
Packaging
10mg
Price
$280
Updated
2024/03/01
TRC
Product number
I940618
Product name
Ivachtin
Packaging
2.5mg
Price
$165
Updated
2021/12/16
ApexBio Technology
Product number
A4417
Product name
Ivachtin
Packaging
10mg
Price
$319
Updated
2021/12/16
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IVACHTIN Chemical Properties,Usage,Production

Uses

Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of caspase-3.

Definition

ChEBI: Acetic acid 2-[4-methyl-8-(4-morpholinylsulfonyl)-1,3-dioxo-2-pyrrolo[3,4-c]quinolinyl]ethyl ester is a pyrroloquinoline.

General Description

A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with larger than 10-fold greater selectivity towards caspase-3 than caspases-1, -2, and -4 through -10. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in preventing Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.

Biological Activity

ivachtin is a potent inhibitor of caspase-3 with ic50 value of 23 nm [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.ivachtin is a potent and reversible inhibitor of caspase-3 in a noncompetitive way. ivachtin was the most potent inhibitor against caspase-3, but the selectivity versus the remaining caspases was modest. in human jurkat t cells treated with 10 μm staurosporin, ivachtin protected cells in a higher level, which suggested that ivachtin had a good cell permeability and antiapoptotic activity [1].

Biochem/physiol Actions

Cell permeable: yes

References

[1]. kravchenko dv, kuzovkova ya, kysil vm, et al. synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. j med chem, 2005, 48(11): 3680-3683.

IVACHTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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745046-84-8, IVACHTINRelated Search:

4-METHYL-2,3-DIHYDRO-1H-PYRROLO[3,4-C]QUINOLINE-1,3-DIONE 2,4-DIMETHYLQUINOLINE-3-CARBOXAMIDE N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE IVACHTIN

  • IVACHTIN
  • 2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate
  • 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
  • modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced
  • 1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-
  • 2-(4-Methyl-8-(morpholinosulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
  • 745046-84-8
  • Inhibitor of caspase-3.