ChemicalBook > CAS DataBase List > IVACHTIN
IVACHTIN
- Product Name
- IVACHTIN
- CAS No.
- 745046-84-8
- Chemical Name
- IVACHTIN
- Synonyms
- IVACHTIN;2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-;2-(4-Methyl-8-(morpholinosulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate;modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced
- CBNumber
- CB82459565
- Molecular Formula
- C20H21N3O7S
- Formula Weight
- 447.46
- MOL File
- 745046-84-8.mol
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IVACHTIN Property
- Boiling point:
- 665.0±65.0 °C(Predicted)
- Density
- 1.459±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- Limited solubility, soluble in DMSO or DMF
- pka
- 1.87±0.20(Predicted)
- form
- Off-white solid
- color
- off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 13306
- Product name
- Caspase-3 Inhibitor VII
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $59
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13306
- Product name
- Caspase-3 Inhibitor VII
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13306
- Product name
- Caspase-3 Inhibitor VII
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2024/03/01
TRC
- Product number
- I940618
- Product name
- Ivachtin
- Packaging
- 2.5mg
- Price
- $165
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A4417
- Product name
- Ivachtin
- Packaging
- 10mg
- Price
- $319
- Updated
- 2021/12/16
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IVACHTIN Chemical Properties,Usage,Production
Uses
Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of caspase-3.
Definition
ChEBI: Acetic acid 2-[4-methyl-8-(4-morpholinylsulfonyl)-1,3-dioxo-2-pyrrolo[3,4-c]quinolinyl]ethyl ester is a pyrroloquinoline.
General Description
A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with larger than 10-fold greater selectivity towards caspase-3 than caspases-1, -2, and -4 through -10. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in preventing Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.
Biological Activity
ivachtin is a potent inhibitor of caspase-3 with ic50 value of 23 nm [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.ivachtin is a potent and reversible inhibitor of caspase-3 in a noncompetitive way. ivachtin was the most potent inhibitor against caspase-3, but the selectivity versus the remaining caspases was modest. in human jurkat t cells treated with 10 μm staurosporin, ivachtin protected cells in a higher level, which suggested that ivachtin had a good cell permeability and antiapoptotic activity [1].
Biochem/physiol Actions
Cell permeable: yes
References
[1]. kravchenko dv, kuzovkova ya, kysil vm, et al. synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. j med chem, 2005, 48(11): 3680-3683.
IVACHTIN Preparation Products And Raw materials
Raw materials
Preparation Products
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745046-84-8, IVACHTINRelated Search:
4-METHYL-2,3-DIHYDRO-1H-PYRROLO[3,4-C]QUINOLINE-1,3-DIONE
2,4-DIMETHYLQUINOLINE-3-CARBOXAMIDE
N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE
IVACHTIN