5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE

Product Name: 5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE
CAS No.: 869640-41-5
Chemical Name: 5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE
Synonyms: 7-benzyl-1,5,6,8-tetrahydro-1,7-naphthyridin-2-one;7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H);7-BENZYL-5,6,7,8-TETRAHYDRO-1,7-NAPHTHYRIDIN-2(1H)-ONE;5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE;1,7-Naphthyridin-2(1H)-one, 5,6,7,8-tetrahydro-7-(phenylmethyl)-
CBNumber: CB82460550
Molecular Formula: C15H16N2O
Formula Weight: 240.3
MOL File: 869640-41-5.mol

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5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE Property

Boiling point:: 492.1±37.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 12.49±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: Y6675
Product name: 7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one
Packaging: 100mg
Price: $301
Updated: 2021/12/16

Activate Scientific

Product number: AS16007
Product name: 7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one
Purity: 95+%
Packaging: 250mg
Price: $378
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0391582
Product name: 7-BENZYL-5,6,7,8-TETRAHYDRO-1,7-NAPHTHYRIDIN-2(1H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $497.92
Updated: 2021/12/16

Alichem

Product number: 869640415
Product name: 7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one
Packaging: 1g
Price: $627.66
Updated: 2021/12/16

Chemenu

Product number: CM141386
Product name: 7-benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one
Purity: 95%
Packaging: 1g
Price: $685
Updated: 2021/12/16

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5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE Chemical Properties,Usage,Production

Synthesis

54920-82-0

100-39-0

869640-41-5

General procedure for the synthesis of 7-benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one from 2-hydroxy-1,7-naphthyridine and benzyl bromide: 2-hydroxy-1,7-naphthyridine (423 mg, 2.89 mmol) was suspended in ethanol (10 mL) and heated for 5 min at 70 °C. Benzyl bromide (0.34 mL, 2.89 mmol) was then slowly added and the mixture was heated to reflux for 3 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and sodium borohydride (0.55 g, 14.5 mmol) was added. The mixture was stirred at 0 °C for 10 min, followed by slow warming to room temperature. 6 M hydrochloric acid (2 mL) was carefully added and stirring was continued for 90 minutes at room temperature. The reaction mixture was alkalized to pH 10 with 2 M sodium hydroxide (10 mL) followed by liquid-liquid partitioning with ethyl acetate (20 mL) and water (10 mL). The organic layer was separated and the aqueous layer was extracted with a dichloromethane/methanol mixture (95:5, 2 x 20 mL). All organic phases were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford 7-benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one as a white solid in 90% yield (626 mg).1H NMR (CD3OD, 400 MHz) δ: 2.62 (m, 2H), 2.76 (m, 2H), 3.42 (s, 2H), 3.71 (s, 2H), 6.36 (d, 1H), 7.26-7.41 (m, 6H).MS APCI+ m/z 241 [MH]+.

References

[1] Patent: EP1595881, 2005, A1. Location in patent: Page/Page column 59
[2] Patent: EP3067356, 2016, A1. Location in patent: Paragraph 0421
[3] Patent: EP3239147, 2017, A1. Location in patent: Paragraph 0169
[4] Patent: WO2018/83136, 2018, A1. Location in patent: Page/Page column 35

5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE Suppliers

China 24 India 1 United States 3 Global 28

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869640-41-5, 5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONERelated Search:

5,6,7,8-TETRAHYDRO-7-(PHENYLMETHYL)-1,7-NAPHTHYRIDIN-2(1H)-ONE

7-BENZYL-5,6,7,8-TETRAHYDRO-1,7-NAPHTHYRIDIN-2(1H)-ONE

7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)

7-benzyl-1,5,6,8-tetrahydro-1,7-naphthyridin-2-one

1,7-Naphthyridin-2(1H)-one, 5,6,7,8-tetrahydro-7-(phenylmethyl)-

869640-41-5