5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 723286-79-1
Chemical Name: 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: 7-N-Boc-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine;7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine;tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H);5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate;tert-butyl 5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate;TERT-BUTYL 5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE;tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate ,99%;5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate hydrochloride;1,2,4-Triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid, 5,6-dihydro-, 1,1-dimethylethyl ester
CBNumber: CB82464558
Molecular Formula: C10H16N4O2
Formula Weight: 224.26
MOL File: 723286-79-1.mol

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5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 378.4±52.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 2.87±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B902675
Product name: tert-Butyl5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143814
Product name: tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
Packaging: 250mg
Price: $67.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143814
Product name: tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
Packaging: 500mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: Y6666
Product name: tert-Butyl5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143814
Product name: tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
Packaging: 1g
Price: $205
Updated: 2021/12/16

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5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Synthesis

68774-77-6

24424-99-5

723286-79-1

8-Chloro-[1,2,4]triazolo[4,3-A]pyrazine (8.10 g) obtained in Step 2 was mixed with platinum (IV) oxide and 10% palladium/carbon (2 g, 50% aqueous content) in methanol (8 mL) and placed under a hydrogen atmosphere (50 psi, Parr unit) and stirred for 34 hours. Upon completion of the reaction, the reaction mixture was filtered through a Hyflo Super Cel and the filtrate was concentrated to give an oil. The oil was dissolved in dichloromethane (200 mL) and N,N-diisopropylethylamine (10 mL) and di-tert-butyl dicarbonate (11.4 g) were added sequentially and the reaction was stirred for 3 hours at room temperature. At the end of the reaction, saturated aqueous sodium bicarbonate solution was added and extracted with chloroform three times. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated. The resulting crude product was purified by silica gel column chromatography to afford 7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (2.55 g, 22% yield).

References

[1] Patent: JP5851663, 2016, B1. Location in patent: Paragraph 0302

5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

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View Lastest Price from 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER 723286-79-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

723286-79-1, 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylic acid tert-Butyl 3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER

5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER

tert-butyl 5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate

TERT-BUTYL 5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE

tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate ,99%

7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine

tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate hydrochloride

7-N-Boc-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine

tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)

5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

1,2,4-Triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid, 5,6-dihydro-, 1,1-dimethylethyl ester

723286-79-1