8-METHOXY-2,4-DICHLOROQUINAZOLINE
- Product Name
- 8-METHOXY-2,4-DICHLOROQUINAZOLINE
- CAS No.
- 61948-59-2
- Chemical Name
- 8-METHOXY-2,4-DICHLOROQUINAZOLINE
- Synonyms
- 5-METHOXY-2,4-DICHLOROQUINAZOLINE;Quinazoline, 2,4-dichloro-5-methoxy-
- CBNumber
- CB82464664
- Molecular Formula
- C9H6Cl2N2O
- Formula Weight
- 229.06
- MOL File
- 61948-59-2.mol
8-METHOXY-2,4-DICHLOROQUINAZOLINE Property
- Melting point:
- 165-166℃
- Density
- 1.450
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D437305
- Product name
- 2,4-Dichloro-5-methoxyquinazoline
- Packaging
- 250mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- FD142054
- Product name
- 2,4-Dichloro-5-methoxyquinazoline
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD142054
- Product name
- 2,4-Dichloro-5-methoxyquinazoline
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 9302AB
- Product name
- 2,4-Dichloro-5-methoxyquinazoline
- Packaging
- 100mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- FD142054
- Product name
- 2,4-Dichloro-5-methoxyquinazoline
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
8-METHOXY-2,4-DICHLOROQUINAZOLINE Chemical Properties,Usage,Production
Uses
2,4-Dichloro-5-methoxyquinazoline is a useful reactant for the synthesis of N2,?N4-?disubstituted quinazoline-?2,?4-?diamines which have been studied as possible antibacterial agents.
Synthesis
61948-86-5
61948-59-2
General procedure for the synthesis of 2,4-dichloro-5-methoxyquinazoline from 5-methoxyquinazoline-2,4(1H,3H)-dione (310 mg, 1.6 mmol): 5-methoxyquinazoline-2,4(1H,3H)-dione was added to a dry flask, followed by phosphorus trichloride (10 mL) and N,N-dimethylaniline (0.2 mL). After the addition was completed, the reaction mixture was heated to reflux for 4 hours. After completion of the reaction, the volatile components were evaporated under reduced pressure to obtain the crude product. Saturated sodium bicarbonate solution was added to the crude product, followed by ethyl acetate for extraction. The organic phase was separated, dried over anhydrous sodium sulfate and filtered. The solvent was again evaporated under reduced pressure to give another crude product. The crude product was purified by silica gel column chromatography with an eluent of 10% to 20% ethyl acetate/hexane mixed solvent, resulting in 2,4-dichloro-5-methoxyquinazoline (180 mg, 49% yield) as a white solid.1H NMR (400 MHz, CDCl3) δppm: 4.03 (s, 3H), 7.02 (d, J=8.35 Hz. 1H), 7.55 (d, J=8.35Hz, 1H), 7.85 (t, J=8.35Hz, 1H).
References
[1] Patent: WO2007/30582, 2007, A2. Location in patent: Page/Page column 92
[2] Journal of the Chemical Society, 1948, p. 1759,1765
[3] Patent: US5688803, 1997, A
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5141 - 5156
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View Lastest Price from 8-METHOXY-2,4-DICHLOROQUINAZOLINE manufacturers
- Product
- 8-METHOXY-2,4-DICHLOROQUINAZOLINE 61948-59-2
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2019-12-20