3-(2,2,2-Trimethylhydrazine)methylpropionate bromide
- Product Name
- 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide
- CAS No.
- 106966-25-0
- Chemical Name
- 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide
- Synonyms
- Meldonium impurity C CRS;3-(2,2,2-Trimethylhydrazinyl)Methyl Propionate Bromide (Thmp);2-(3-Methoxy-3-oxopropyl)-1,1,1-trimethylhydrazin-1-ium Bromide;3-(2,2,2-Trimethylhydrazinyl)-propanoic acid methyl ester bromide;PROPANOIC ACID, 3-(2,2,2-TRIMETHYLHYDRAZINYL)-, METHYL ESTER BROMIDE;Hydrazinium, 2-(3-methoxy-3-oxopropyl)-1,1,1-trimethyl-, bromide (1:1)
- CBNumber
- CB82464705
- Molecular Formula
- C7H17N2O2.Br
- Formula Weight
- 241.127
- MOL File
- 106966-25-0.mol
3-(2,2,2-Trimethylhydrazine)methylpropionate bromide Property
- Density
- 1.38 at 20℃
- vapor pressure
- 5hPa at 20-25℃
- LogP
- -3.26 at 24℃ and pH6.2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CHM0377436
- Product name
- 3-(2,2,2-TRIMETHYLHYDRAZINYL)-PROPANOIC ACID METHYL ESTER BROMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.25
- Updated
- 2021/12/16
3-(2,2,2-Trimethylhydrazine)methylpropionate bromide Chemical Properties,Usage,Production
Uses
3-(2,2,2-Trimethylhydrazine)methylpropionate bromide can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Synthesis
In a three-necked round bottom flask equipped with a mechanical stirrer, a dropping funnel and a reflux condenser, 172 g (2 mol) of methyl acrylate was added, and under cooling, 132 g (2.2 mol) of 1,1-dimethylhydrazine was added dropwise. After a period of 2 hours, the reaction mixture was heated at the same temperature until methyl 3-(2,2-dimethylhydrazo)propionate was formed (monitored by GM-MS). The above methyl 3-(2,2-dimethylhydrazinyl)propanoate product was dissolved in 40% ethanol (350 ml), cooled to 0 ° C, and methyl bromide (189 g, 1.99 mol) was passed for 1 hour, and the temperature was continued. After stirring for 0, 5 hours, the yellow or brown precipitate was filtered off, and the crude product was washed with acetone (1000 ml). The crude 3-(2,2,2-trimethylhydrazine) propionate methyl bromide was dried (265.7 g, yield 91.0%); the crude product was recrystallized from ethanol and dried to give 219.8 g of pale yellow crystalline powder. The rate is 75.3%, the melting point is 130-132°C, and the main content is 103.3%. (The stability is verified by the stability test. The stability is poor, the color gradually becomes deeper. Because the trace impurities contained in the product have a great influence on the product, it is found to have molecular decay and various indicators. Larger, the product is valid for up to two years).