HDH-PHARMA 24754
- Product Name
- HDH-PHARMA 24754
- CAS No.
- 630120-99-9
- Chemical Name
- HDH-PHARMA 24754
- Synonyms
- HDH-PHARMA;HDH-PHARMA 24754;5-(Benzyloxy)-2-broMopyridine;2-BROMO-5-(PHENYLMETHOXY)-PYRIDINE;PYRIDINE, 2-BROMO-5-(PHENYLMETHOXY)-
- CBNumber
- CB82465393
- Molecular Formula
- C12H10BrNO
- Formula Weight
- 264.12
- MOL File
- 630120-99-9.mol
HDH-PHARMA 24754 Property
- Boiling point:
- 366.5±27.0 °C(Predicted)
- Density
- 1.438±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -2.25±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B291543
- Product name
- 5-(Benzyloxy)-2-bromopyridine
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- CS-0046861
- Product name
- 5-(Benzyloxy)-2-bromopyridine
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0046861
- Product name
- 5-(Benzyloxy)-2-bromopyridine
- Packaging
- 5g
- Price
- $359
- Updated
- 2021/12/16
- Product number
- Z0742
- Product name
- 5-Benzyloxy-2-bromopyridine
- Packaging
- 5g
- Price
- $431
- Updated
- 2021/12/16
- Product number
- SC-60540
- Product name
- PYRIDINE,2-BROMO-5-(PHENYLMETHOXY)-
- Purity
- 95
- Packaging
- 5g
- Price
- $462
- Updated
- 2021/12/16
HDH-PHARMA 24754 Chemical Properties,Usage,Production
Synthesis
55717-45-8
100-51-6
630120-99-9
To a 1 L round bottom flask equipped with a large stirrer was added 6-bromopyridin-3-ol (24.69 g, 142 mmol), benzyl alcohol (15.42 mL, 149 mmol), triphenylphosphine (39.1 g, 149 mmol) and tetrahydrofuran (600 mL). The flask was placed in a room temperature water bath. Diisopropyl azodicarboxylate (DIAD, 29.0 mL, 149 mmol) was added to the stirred solution in six batches. The internal temperature was increased from 20 °C to 35 °C during the reaction and maintained at 35 °C after the addition was completed. After stirring the reaction for 18 hours, the reaction solution was concentrated under reduced pressure to give a liquid residue. This residue was diluted with a solvent mixture of hexane and ether (1:1, 850 mL), and precipitate generation was immediately observed. The mixture was stirred for 5 minutes and then decanted and the supernatant retained. The solid fraction was treated with ether (200 mL) and stirred again for 5 minutes. Subsequently, hexane (200 mL) was added to the solution and stirring was continued for 5 minutes. The above treated mixture was combined with the previously retained supernatant and vacuum filtered through a fine pore sintered glass funnel. The filtrate was concentrated under reduced pressure and the resulting residue was dissolved in a small amount of acetone and concentrated again under reduced pressure onto diatomaceous earth. The resulting powder was separated by silica gel column chromatography (using a 330 g silica gel column with a gradient ratio of hexane/ethyl acetate, 100:0 to 80:20, as eluent), resulting in 5-(benzyloxy)-2-bromopyridine as a colorless crystalline solid (24.84 g, 66% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 8.16 (d, J = 3.2 Hz, 1H), 7.45-7.36 (m, 6H), 7.18 (dd, J = 8.6,3.2 Hz, 1H), 5.12 (s, 2H).
References
[1] Patent: WO2018/127800, 2018, A1. Location in patent: Page/Page column 71; 72
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1370 - 1387
[3] Patent: WO2009/140163, 2009, A1. Location in patent: Page/Page column 37
HDH-PHARMA 24754 Preparation Products And Raw materials
Raw materials
Preparation Products
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