3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER

Product Name: 3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER
CAS No.: 75418-74-5
Chemical Name: 3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER
Synonyms: Methyl 3-oxo-3-(pyridin-2-yl);methyl 3-oxo-3-(pyridin-2-yl)propanoate;2-Pyridinepropanoic acid, β-oxo-, methyl ester;3-Oxo-3-pyridin-2-ylpropanoic acid methyl ester;3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER
CBNumber: CB82465494
Molecular Formula: C9H9NO3
Formula Weight: 179.17
MOL File: 75418-74-5.mol

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3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER Property

storage temp.: Inert atmosphere,Room Temperature
Appearance: Brown to reddish brown Liquid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: M325860
Product name: Methyl3-Oxo-3-(pyridin-2-yl)propanoate
Packaging: 500mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: 1722AC
Product name: Methyl3-oxo-3-(pyridin-2yl)propanoate
Packaging: 1g
Price: $145
Updated: 2021/12/16

Apolloscientific

Product number: OR932268
Product name: Methyl3-oxo-3-(pyridin-2-yl)propanoate
Purity: 95%
Packaging: 1g
Price: $240
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0393090
Product name: METHYL-3-OXO-3-(PYRIDIN-2YL)PROPANOATE
Purity: 95.00%
Packaging: 5MG
Price: $500.28
Updated: 2021/12/16

AK Scientific

Product number: 1722AC
Product name: Methyl3-oxo-3-(pyridin-2yl)propanoate
Packaging: 25g
Price: $967
Updated: 2021/12/16

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3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

1122-62-9

616-38-6

75418-74-5

Step 2: Preparation of methyl 3-oxo-3-pyridin-2-ylpropionate; NaH (60% mineral oil suspension; 30 g, 750 mmol, 2.5 eq.) was suspended in cyclohexane (900 mL) and the temperature was raised to reflux. To this suspension 2-acetylpyridine (36 g, 300 mmol) was added dropwise for 10 minutes followed by dimethyl carbonate (100 mL, 1.2 mol, 4 eq.). The reaction mixture was heated to reflux for 4 hours, followed by standing at room temperature overnight and then cooled to 0 °C. The near-solid mixture was quenched by adding a solution of AcOH (75 mL) in water (250 mL), followed by dilution with Et2O (250 mL) and stirring until all solids were completely dissolved. The aqueous layer was separated and extracted with Et2O (2 x 250 mL). The organic extracts were combined, dried with MgSO4 and concentrated under reduced pressure. The crude product was purified by distillation to afford the recovered 2-acetylpyridine (40 °C/0.3 mbar; 6.5 g, 18%) and the target product methyl 3-oxo-3-pyridin-2-ylpropionate (105 °C/0.6 mbar; 27.5 g, 51%).

References

[1] Patent: US2008/161254, 2008, A1. Location in patent: Page/Page column 14
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 2, p. 836 - 851
[3] Chemical Communications, 2012, vol. 48, # 17, p. 2340 - 2342
[4] Tetrahedron Letters, 2014, vol. 55, # 48, p. 6534 - 6537
[5] Organic Letters, 2014, vol. 16, # 20, p. 5410 - 5413

3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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75418-74-5, 3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTERRelated Search:

methyl 3-oxo-3-(pyridin-2-yl)propanoate

3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER

Methyl 3-oxo-3-(pyridin-2-yl)

2-Pyridinepropanoic acid, β-oxo-, methyl ester

3-Oxo-3-pyridin-2-ylpropanoic acid methyl ester

75418-74-5