2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-
- Product Name
- 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-
- CAS No.
- 488713-31-1
- Chemical Name
- 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-
- Synonyms
- 5-amino-3-chloropicolinonitrile;5-Amino-3-chloro-2-cyanopyridine;5-AMino-3-chloropyridine-2-carbonitrile;5-Amino-3-chloro-2-pyridinecarbonitrile;2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-
- CBNumber
- CB82468581
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 488713-31-1.mol
2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO- Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A605313
- Product name
- 5-amino-3-chloropicolinonitrile
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 153084
- Product name
- 5-Amino-3-chloropicolinonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $926
- Updated
- 2021/12/16
- Product number
- 7985BB
- Product name
- 5-Amino-3-chloropicolinonitrile
- Packaging
- 5g
- Price
- $1414
- Updated
- 2021/12/16
- Product number
- 153084
- Product name
- 5-Amino-3-chloropicolinonitrile
- Purity
- 95%
- Packaging
- 5g
- Price
- $2766
- Updated
- 2021/12/16
- Product number
- 7985BB
- Product name
- 5-Amino-3-chloropicolinonitrile
- Packaging
- 25g
- Price
- $4042
- Updated
- 2021/12/16
2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO- Chemical Properties,Usage,Production
Synthesis
488713-30-0
488713-31-1
(Step 3) (1068) 3-Chloro-5-nitropyridine-2-carbonitrile (0.18 g, 0.984 mmol) was dissolved in ethanol (6.0 mL), and stannic chloride (II) (0.929 g, 4.918 mmol) was added. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, it was cooled to room temperature and the pH was adjusted with saturated aqueous sodium bicarbonate to 7. The reaction mixture was extracted with ethyl acetate (3×), the organic layer was washed sequentially with water and saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give 5-amino-3-chloropyridine-2-carbonitrile (0.13 g, 87% yield) as an off-white solid.1H-NMR (400 MHz, DMSO-d6): δ 6.77 (broad single peak, 2H), 7.05 (d, 1H, J=2.32 Hz), 7.94 (d, 1H, J=2.28 Hz).
References
[1] Patent: EP2975031, 2016, A1. Location in patent: Paragraph 1068
[2] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0507
[3] Patent: WO2004/50637, 2004, A2. Location in patent: Page 66-67
[4] Patent: US2003/114457, 2003, A1
2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO- Preparation Products And Raw materials
Raw materials
Preparation Products
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