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SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE

Product Name
SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE
CAS No.
252882-61-4
Chemical Name
SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE
Synonyms
SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE;spiro[1H-indole-3,4'-piperidine]-2-one;Spiro[3H-indole-3,4'-piperidin]-2(1H)-one;1,2-dihydrospiro[indole-3,4'-piperidine]-2-one;Spiro[indoline-3,4'-piperidin]-2-one - [S13046];1,2-Dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
CBNumber
CB82468839
Molecular Formula
C12H14N2O
Formula Weight
202.25
MOL File
252882-61-4.mol
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SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE Property

Boiling point:
413.2±45.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
13.94±0.20(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
S683048
Product name
Spiro[indoline-3,4''-piperidin]-2-one
Packaging
50mg
Price
$110
Updated
2021/12/16
Synthonix
Product number
S13046
Product name
Spiro[indoline-3,4'-piperidin]-2-one
Purity
95+%
Packaging
250mg
Price
$260
Updated
2021/12/16
AK Scientific
Product number
W4860
Product name
Spiro[indoline-3,4'-piperidin]-2-one
Packaging
1g
Price
$358
Updated
2021/12/16
Matrix Scientific
Product number
073803
Product name
Spiro[indoline-3,4'-piperidin]-2-one
Purity
95+%
Packaging
250mg
Price
$537
Updated
2021/12/16
Matrix Scientific
Product number
073803
Product name
Spiro[indoline-3,4'-piperidin]-2-one
Purity
95+%
Packaging
1g
Price
$1158
Updated
2021/12/16
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SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE Chemical Properties,Usage,Production

Synthesis

1086063-19-5

252882-61-4

Method 1: Procedure for the synthesis of spiro[indolin-3,4'-piperidin]-2-one. Hydroxyindole (3.00 g, 22.5 mmol) was dissolved in tetrahydrofuran (20 mL) under argon protection, and a tetrahydrofuran solution (20 mL) with benzylbis(2-chloroethyl)amine (5.20 g, 22.5 mmol) was added sequentially to tetrahydrofuran (100 mL). Sodium hydride (1.60 g, 67.6 mmol) was added at room temperature and the mixture was stirred at the same temperature for 1 hour, then warmed up to 90 °C and continued stirring for 3 hours. After the reaction solution was cooled to room temperature, a tetrahydrofuran solution (10 mL) of sodium hydride (0.540 g, 22.5 mmol) was added and stirring was continued at 90 °C for 12 hours. After the reaction was completed, saturated aqueous ammonium chloride solution was added and stirred for 10 min at room temperature. The mixture was poured into a mixture of saturated aqueous sodium bicarbonate solution and brine and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: chloroform:methanol=20:1) to afford 1'-benzylspiro[indoline-3,4'-piperidin]-2-one (2.94 g, 44.6% yield) as a yellow amorphous solid.1H-NMR (400 MHz, CDCl3) δ: 1.78-1.93 (m, 2H), 1.95-2.06 (m, 2H), 2.65-2.06 (m, 2H). 2H), 2.65-2.77 (m, 2H), 2.87-3.00 (m, 2H), 3.69 (s, 2H), 6.90 (d, J=7.6Hz, 1H), 7.02 (t, J=7.6Hz, 1H), 7.20 (t, J=7.6Hz, 1H), 7.26 (t, J=6.2Hz, 1H), 7.34 (t, J=6.2Hz, 1H), 7.34 (t, J=7.6Hz, 1H). J=7.6 Hz, 2H), 7.40-7.41 (m, 3H), 8.72 (s, 1H). 1'-Benzylspiro[indoline-3,4'-piperidin]-2-one (300 mg, 1.03 mmol) was dissolved in methanol (5 mL) and 10% palladium carbon (30.0 mg) was added. The mixture was stirred at room temperature under hydrogen atmosphere for 15 hours. The reaction solution was filtered through diatomaceous earth and concentrated under reduced pressure to give spiro[indoline-3,4'-piperidin]-2-one (187 mg, 90.2% yield) as a colorless amorphous solid.1H-NMR (400 MHz, CDCl3) δ: 1.73-1.78 (m, 2H), 1.88-1.94 (m, 2H), 3.06-3.12 (m, 2H) , 3.35-3.41 (m, 2H), 6.92 (d, J=7.7Hz, 1H), 7.04 (t, J=7.7Hz, 1H), 7.22 (t, J=7.7Hz, 1H), 7.42 (d, J=7.7Hz, 1H), 8.70 (br, 1H).

References

[1] Patent: US2008/306102, 2008, A1. Location in patent: Page/Page column 12
[2] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 2, p. 94 - 97
[3] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 36

SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE Suppliers

China 55 India 1 United States 5 Global 61
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
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21-57721279
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Nanjing JinruiJiuAn Biotechnology Co., Ltd.
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025-58196018 800028039
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sales@fartop.net
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Shanghai Keepontech Co.,Ltd
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021-54849683 13601642561
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+86-21-54375689
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sales@keepontech.com
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9ding chemical ( Shanghai) Limited
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4009209199
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86-021-52271987
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sales@9dingchem.com
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Shanghai Raise Chemical Technology Co.,Ltd
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+86-021-50935922
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+86-021-33847795
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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Nantong MYBio-pharm. Co., Ltd.
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Shanghai XR Chemical Technology Co., Ltd.
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021-31007982 18019432809
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info@xrpharma.com
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Hangzhou Milestone Pharmtech Co., Ltd.
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0571-82896630 18969958410
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sales_hz@milestonepharmtech.com
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NovoChemy Ltd.
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252882-61-4, SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONERelated Search:

SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE SPIRO[2.5]OCTAN-6-ONE 4-OXO-2-SPIRO(PIPERIDINE-4-YL)-BENZOPYRAN HYDROCHLORIDE CHEMBRDG-BB 4011973 SPIRO[2.2]PENTANE-1-CARBOXYLIC ACID Spiro[3.3]heptane-2,6-dicarboxylic acid, 2,6-dimethyl ester SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE Spiro[bicyclo[2.2.1]heptane-2,2’-[1,3]dioxolan]-5-one SPIRO[IMIDAZOLIDINE-4,3-INDOLINE]-2,2,5-TRIONE Spiro[bicyclo[2.2.1]hept[5]ene-2,2’-[1,3]dioxolan]-5-yl Trifluoromethanesulfonate 1'-N-BOC-1,2-DIHYDRO-1'H-SPIRO[INDOLE-3,4'-PIPERIDINE] spiro[indole-3,3-pyrrolidin]-2(1H)-one hydrochloride

  • SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE
  • 1,2-dihydrospiro[indole-3,4'-piperidine]-2-one
  • Spiro[3H-indole-3,4'-piperidin]-2(1H)-one
  • 1,2-Dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
  • spiro[1H-indole-3,4'-piperidine]-2-one
  • Spiro[indoline-3,4'-piperidin]-2-one - [S13046]
  • 252882-61-4