2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE
- Product Name
- 2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE
- CAS No.
- 1127-85-1
- Chemical Name
- 2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE
- Synonyms
- 2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE;Quinazoline, 2,4-dichloro-5,6,7,8-tetrahydro-
- CBNumber
- CB82468925
- Molecular Formula
- C8H8Cl2N2
- Formula Weight
- 203.07
- MOL File
- 1127-85-1.mol
2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE Property
- Melting point:
- 72-73 °C
- Boiling point:
- 325.6±42.0 °C(Predicted)
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -1.77±0.20(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B419305
- Product name
- 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B419305
- Product name
- 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 074540
- Product name
- 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FD43460
- Product name
- 2,4-dichloro-5,6,7,8-tetrahydroquinazoline
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FD43460
- Product name
- 2,4-dichloro-5,6,7,8-tetrahydroquinazoline
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE Chemical Properties,Usage,Production
Synthesis
35042-48-9
1127-85-1
General procedure for the synthesis of 2,4-dichloro-5,6,7,8-tetrahydroquinazoline from 5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione: 5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione (8.0 g) was mixed with phosphorochloridic acid chloride (40 mL) and reacted at 120 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and the excess phosphoryl chloride was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (400 mL) and water (200 mL) for partitioning. The organic phase was washed sequentially with saturated NaHCO3 solution (200 mL) and brine (200 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography to afford 2,4-dichloro-5,6,7,8-tetrahydroquinazoline (4.0 g, 57% yield) as a yellow solid.1H NMR (400 MHz, CDCl3) δ 1.8 (br s, 4H), 2.73 (br s, 2H), 2.88 (br s, 2H).MS m/z (M+H): 203.1.
References
[1] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00688
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 2, p. 510 - 524
2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE Suppliers
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- India
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View Lastest Price from 2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE manufacturers
- Product
- 2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE 1127-85-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-07-16
- Product
- 2,4-Dichloro-5,6,7,8-tetrahydro-quinazoline 1127-85-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 2,4-DICHLORO-5,6,7,8-TETRAHYDROQUINAZOLINE 1127-85-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%min
- Supply Ability
- as request
- Release date
- 2018-12-22