ChemicalBook > CAS DataBase List > 4-Bromo-2-(trifluoromethoxy)benzoic acid

4-Bromo-2-(trifluoromethoxy)benzoic acid

Product Name
4-Bromo-2-(trifluoromethoxy)benzoic acid
CAS No.
509142-48-7
Chemical Name
4-Bromo-2-(trifluoromethoxy)benzoic acid
Synonyms
4-Bromo-2-(trifluoromethoxy)benzoic acid;Benzoic acid, 4-bromo-2-(trifluoromethoxy)-
CBNumber
CB82470124
Molecular Formula
C8H4BrF3O3
Formula Weight
285.01
MOL File
509142-48-7.mol
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4-Bromo-2-(trifluoromethoxy)benzoic acid Property

Melting point:
91～94℃
Boiling point:
272.7±40.0 °C(Predicted)
Density 
1.797±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
2.69±0.36(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B695198
Product name
4-Bromo-2-(trifluoromethoxy)benzoicacid
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
B695198
Product name
4-Bromo-2-(trifluoromethoxy)benzoicacid
Packaging
100mg
Price
$45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0070344
Product name
4-BROMO-2-(TRIFLUOROMETHOXY)BENZOIC ACID
Purity
95.00%
Packaging
1G
Price
$680.3
Updated
2021/12/16
Matrix Scientific
Product number
058518
Product name
4-Bromo-2-(trifluoromethoxy)benzoic acid
Purity
98%
Packaging
25g
Price
$123
Updated
2021/12/16
SynQuest Laboratories
Product number
2621-B-0B
Product name
4-Bromo-2-(trifluoromethoxy)benzoic acid
Packaging
25g
Price
$234
Updated
2021/12/16
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4-Bromo-2-(trifluoromethoxy)benzoic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Synthesis

288315-03-7

122-01-0

509142-48-7

GENERAL STEPS: Example 63 (a) Synthesis of 4-bromo-2-(trifluoromethoxy)benzoic acid Thionyl chloride (5 mL) was added to 4-chlorobenzoic acid (0.49 g, 3.1 mmol). After addition of 2 drops of anhydrous DMF, the reaction mixture was refluxed under nitrogen protection for about 15 min. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was dissolved in dichloromethane (5 mL). Subsequently, 3,3-difluoroazetidine hydrochloride (0.42 g, 3.3 mmol) and triethylamine (0.91 mL, 6.6 mmol) were added. The reaction mixture was stirred at room temperature for about 15 minutes. The reaction solution was diluted with dichloromethane and washed sequentially with saturated aqueous sodium bicarbonate solution and water. The organic phase was treated with anhydrous ethanol (until a clarified solution was obtained) and the solvent was evaporated in vacuum to give 4-bromo-2-trifluoromethoxybenzoic acid as a solid in 94% yield. The resulting product could be used in the next reaction without further purification. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.75-7.66 (m, 2H), 7.58-7.48 (m, 2H), 5.06-4.15 (m, 4H); MS (ESI) m/z 232 (M + 1).

References

[1] Patent: WO2007/40440, 2007, A1. Location in patent: Page/Page column 115-116

4-Bromo-2-(trifluoromethoxy)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromo-2-(trifluoromethoxy)benzoic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Bromo-2-(trifluoromethoxy)benzoic acid 509142-48-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Bromo-2-(trifluoromethoxy)benzoic acid 509142-48-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
4-Bromo-2-(trifluoromethoxy)benzoic acid 509142-48-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-25

509142-48-7, 4-Bromo-2-(trifluoromethoxy)benzoic acidRelated Search:

2-(Trifluoromethoxy)benzoic acid

  • 4-Bromo-2-(trifluoromethoxy)benzoic acid
  • Benzoic acid, 4-bromo-2-(trifluoromethoxy)-
  • 509142-48-7