Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate

Product Name: Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
CAS No.: 1080026-94-3
Chemical Name: Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Synonyms: ethyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-2-carboxylate;Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate;4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid ethyl ester;Thieno[3,2-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-, ethyl ester
CBNumber: CB82470199
Molecular Formula: C10H13NO2S
Formula Weight: 211.28
MOL File: 1080026-94-3.mol

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Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E926435
Product name: Ethyl4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Packaging: 25mg
Price: $50
Updated: 2021/12/16

Usbiological

Product number: 449314
Product name: Ethyl 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Packaging: 25mg
Price: $312
Updated: 2021/12/16

AK Scientific

Product number: X8860
Product name: Ethyl4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Packaging: 100mg
Price: $145
Updated: 2021/12/16

Matrix Scientific

Product number: 072458
Product name: Ethyl 4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-2-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $416
Updated: 2021/12/16

AK Scientific

Product number: X8860
Product name: Ethyl4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Packaging: 1g
Price: $428
Updated: 2021/12/16

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Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Chemical Properties,Usage,Production

Synthesis

623564-30-7

1080026-94-3

General procedure for the synthesis of ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate from ethyl 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate: to a 100 mL round-bottom flask containing ethyl 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (1 g. 3.21 mmol) in a 100 mL round-bottomed flask was added to dichloromethane (16 mL) followed by slow addition of trifluoroacetic acid (1.48 mL, 19.3 mmol). The reaction mixture was stirred at room temperature for 60 minutes. After the reaction was completed, saturated aqueous sodium bicarbonate (10 mL) and dichloromethane (10 mL) were added to the mixture. After separating the organic layer, the aqueous phase was extracted twice with dichloromethane (20 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the oily product ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (0.547 g, 81% yield).LCMS(FA)ES+: m/z 212.

References

[1] Patent: WO2010/151317, 2010, A1. Location in patent: Page/Page column 108
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7201 - 7211
[3] MedChemComm, 2016, vol. 7, # 5, p. 960 - 965
[4] Patent: WO2012/117421, 2012, A1. Location in patent: Page/Page column 40
[5] Patent: US2010/99664, 2010, A1. Location in patent: Page/Page column 32

Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Preparation Products And Raw materials

Raw materials

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Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Suppliers

China 29 Germany 1 India 2 United States 8 Global 40

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1080026-94-3, Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylateRelated Search:

Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate

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ethyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-2-carboxylate

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1080026-94-3

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