Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate

Product Name: Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
CAS No.: 1080026-94-3
Chemical Name: Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Synonyms: ethyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-2-carboxylate;Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate;4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid ethyl ester;Thieno[3,2-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-, ethyl ester
CBNumber: CB82470199
Molecular Formula: C10H13NO2S
Formula Weight: 211.28
MOL File: 1080026-94-3.mol

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Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 449314
Product name: Ethyl 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Packaging: 25mg
Price: $312
Updated: 2021/12/16

TRC

Product number: E926435
Product name: Ethyl4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Packaging: 25mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: X8860
Product name: Ethyl4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
Packaging: 100mg
Price: $145
Updated: 2021/12/16

Matrix Scientific

Product number: 072458
Product name: Ethyl 4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-2-carboxylate
Purity: 95+%
Packaging: 1g
Price: $899
Updated: 2021/12/16

Matrix Scientific

Product number: 072458
Product name: Ethyl 4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-2-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $416
Updated: 2021/12/16

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Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Chemical Properties,Usage,Production

Synthesis

623564-30-7

1080026-94-3

General procedure for the synthesis of ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate from ethyl 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate: to a 100 mL round-bottom flask containing ethyl 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (1 g. 3.21 mmol) in a 100 mL round-bottomed flask was added to dichloromethane (16 mL) followed by slow addition of trifluoroacetic acid (1.48 mL, 19.3 mmol). The reaction mixture was stirred at room temperature for 60 minutes. After the reaction was completed, saturated aqueous sodium bicarbonate (10 mL) and dichloromethane (10 mL) were added to the mixture. After separating the organic layer, the aqueous phase was extracted twice with dichloromethane (20 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the oily product ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (0.547 g, 81% yield).LCMS(FA)ES+: m/z 212.

References

[1] Patent: WO2010/151317, 2010, A1. Location in patent: Page/Page column 108
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7201 - 7211
[3] MedChemComm, 2016, vol. 7, # 5, p. 960 - 965
[4] Patent: WO2012/117421, 2012, A1. Location in patent: Page/Page column 40
[5] Patent: US2010/99664, 2010, A1. Location in patent: Page/Page column 32

Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Suppliers

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1080026-94-3, Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylateRelated Search:

Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate

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ethyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-2-carboxylate

Thieno[3,2-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-, ethyl ester

1080026-94-3

Heterocycle-Pyridine series