2-Bromoimidazo[2,1-b][1,3,4]thiadiazole
- Product Name
- 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole
- CAS No.
- 1137142-58-5
- Chemical Name
- 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole
- Synonyms
- 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole;Imidazo[2,1-b]-1,3,4-thiadiazole, 2-bromo-
- CBNumber
- CB82471343
- Molecular Formula
- C4H2BrN3S
- Formula Weight
- 204.05
- MOL File
- 1137142-58-5.mol
2-Bromoimidazo[2,1-b][1,3,4]thiadiazole Property
- Density
- 2.34±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.74±0.50(Predicted)
- Appearance
- Light yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B696340
- Product name
- 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- X0177
- Product name
- 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole
- Packaging
- 250mg
- Price
- $128
- Updated
- 2021/12/16
- Product number
- 073353
- Product name
- 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $324
- Updated
- 2021/12/16
- Product number
- 35769
- Product name
- 2-Bromoimidazo[2,1-β][1,3,4]thiadiazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $440
- Updated
- 2021/12/16
- Product number
- 073353
- Product name
- 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $700
- Updated
- 2021/12/16
2-Bromoimidazo[2,1-b][1,3,4]thiadiazole Chemical Properties,Usage,Production
Synthesis
107-20-0
37566-39-5
1137142-58-5
The general procedure for the synthesis of 2-bromoimidazo[2,1-b][1,3,4]thiadiazole from chloroacetaldehyde and 2-amino-5-bromo-1,3,4-thiadiazole was as follows: 1. Preparation of Intermediate 3: To an aqueous (27 mL) suspension of 2-amino-5-bromo-1,3,4-thiadiazole (1.65 g, 9.15 mmol) was added a 50% wt aqueous chloroacetaldehyde solution (1.7 mL). 2. The reaction mixture was stirred under reflux conditions for 10 hours. 3. Subsequently, 1.5 equivalents of chloroacetaldehyde (1.7 mL) was added again and stirring was continued until the feedstock was completely consumed (approximately 20 hours). 4. Upon completion of the reaction, the mixture was cooled to room temperature and neutralized with saturated aqueous sodium bicarbonate. 5. The reaction mixture was extracted with dichloromethane (3 x 30 mL) and the organic layers were combined. 6. The organic layer was dried with anhydrous sodium sulfate, followed by evaporation of the solvent under reduced pressure. 7. The crude product was ground with ether to give 2-bromoimidazo[2,1-b][1,3,4]thiadiazole as a white solid. 8. The mother liquor was further purified by fast chromatography (Biotage?, eluent: ethyl acetate/hexane, 3:7 to 7:3) to obtain another batch of the target compounds in a total yield of 20%. Product characterization: 1H NMR (300 MHz, CDCl3): δ 7.64 (s, 1H), 7.24 (s, 1H). MS (ES+) m/z: 204 (M + H)+ (MW: 204.05).
References
[1] Patent: WO2009/40552, 2009, A2. Location in patent: Page/Page column 51
[2] Patent: WO2010/112874, 2010, A1. Location in patent: Page/Page column 53
[3] Patent: WO2010/12345, 2010, A1. Location in patent: Page/Page column 53-54
2-Bromoimidazo[2,1-b][1,3,4]thiadiazole Preparation Products And Raw materials
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View Lastest Price from 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole manufacturers
- Product
- 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole 1137142-58-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-28