2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine

2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine Property

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Off-white to yellow Solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

1. 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (600 mg, 3.19 mmol) and N,N-dimethylformamide (DMF, 5 mL) were added to a round-bottomed flask and stirred until completely dissolved. 2. Add iodomethane (544 mg, 3.83 mmol) and cesium carbonate (520 mg, 1.60 mmol) to the reaction system sequentially. 3. Stir the reaction for 24 hours at room temperature. 4. 4. After completion of the reaction, the reaction solution was poured into water and extracted with ethyl acetate. 5. The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give a yellow solid product. 6. Yield: 91%.

References

[1] Patent: CN107312006, 2017, A. Location in patent: Paragraph 0037-0039
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3486 - 3492
[3] Patent: CN104177363, 2018, B. Location in patent: Paragraph 0247; 0250-0251
[4] Patent: WO2015/193168, A1. Location in patent: Page/Page column 59
[4] Patent: , 2015, . Location in patent: Page/Page column 59