CP-547632

ChemicalBook > CAS DataBase List > CP-547632

Product Name: CP-547632
CAS No.: 252003-65-9
Chemical Name: CP-547632
Synonyms: CS-1957;CP-547632;CP-547632(CP 547632);CP-547632 (PAN-90806);3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami;3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide;3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide;3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
CBNumber: CB82473822
Molecular Formula: C20H24BrF2N5O3S
Formula Weight: 532.4
MOL File: 252003-65-9.mol

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CP-547632 Property

Boiling point:: 548.6±50.0 °C(Predicted)
Density: 1.532
storage temp.: 2-8°C
solubility: DMSO: 94 mM
form: A solid
pka: 12.50±0.70(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21773
Product name: CP 547,632
Purity: ≥98%
Packaging: 500μg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21773
Product name: CP 547,632
Purity: ≥98%
Packaging: 1mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 21773
Product name: CP 547,632
Purity: ≥98%
Packaging: 5mg
Price: $437
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FB102944
Product name: 3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide
Packaging: 1mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0003189
Product name: CP-547632
Purity: >99.0%
Packaging: 5mg
Price: $95
Updated: 2021/12/16

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CP-547632 Chemical Properties,Usage,Production

Description

CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC₅₀ values of 11 and 9 nM, respectively, in an enzyme assay. It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC₅₀ = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC₅₀ = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.

CP-547632 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CP-547632 manufacturers

Career Henan Chemical Co

Product: CP-547632 252003-65-9
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

252003-65-9, CP-547632Related Search:

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CP-547632(CP 547632)

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3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide

252003-65-9

C20H24BrF2N5O3S