1-Boc-3-aminoindazole

Product Name: 1-Boc-3-aminoindazole
CAS No.: 1204298-58-7
Chemical Name: 1-Boc-3-aminoindazole
Synonyms: 1-Boc-3-aminoindazole;tert-Butyl 3-aMino-1H-indazole-1-carboxylate;1H-Indazole-1-carboxylic acid, 3-amino-, 1,1-dimethylethyl ester
CBNumber: CB82474465
Molecular Formula: C12H15N3O2
Formula Weight: 233.27
MOL File: 1204298-58-7.mol

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1-Boc-3-aminoindazole Property

Boiling point:: 395.3±34.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.97±0.50(Predicted)
Appearance: Yellow to brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B701915
Product name: tert-Butyl3-Amino-1H-indazole-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B701915
Product name: tert-Butyl3-Amino-1H-indazole-1-carboxylate
Packaging: 50mg
Price: $175
Updated: 2021/12/16

TRC

Product number: B701915
Product name: tert-Butyl3-Amino-1H-indazole-1-carboxylate
Packaging: 100mg
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: Y5787
Product name: tert-Butyl3-amino-1H-indazole-1-carboxylate
Packaging: 100mg
Price: $228
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0394026
Product name: TERT-BUTYL-3-AMINO-1H-INDAZOLE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $496.89
Updated: 2021/12/16

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1-Boc-3-aminoindazole Chemical Properties,Usage,Production

Synthesis

24424-99-5

874-05-5

1204298-58-7

General procedure for the synthesis of tert-butyl 3-amino-1H-imidazole-1-carboxylate from di-tert-butyl dicarbonate and 3-aminoindazole: first, 150 mg (1.13 mmol) of 1H-indazol-3-amine was dissolved in 3 mL of THF, followed by the addition of 320 mg (1.46 mmol) of di-tert-butyl dicarbonate, 137 mg (1.35 mmol) of triethylamine, and 48 mg (0.39 mmol) of 4-dimethylaminopyridine. The reaction mixture was stirred at room temperature for 1.5 hours. After completion of the reaction, the reaction solution was diluted with ethyl acetate and washed sequentially with water, saturated aqueous ammonium chloride solution and saturated sodium chloride solution each. The organic phase was dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated. The residue was purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, 3:1→1:1) to give 126 mg of tert-butyl 3-amino-1H-imidazole-1-carboxylate in 48% yield.LC-MS (Method 2): Rt = 0.88 min; MS (ESpos): m/z = 234 (M + H)+; 1H-NMR (400 MHz. DMSO-d6): δ = 1.58 (s, 9H), 6.30 (s, 2H), 7.25 (t, 1H), 7.50 (t, 1H), 7.82 (d, 1H), 7.94 (d, 1H).

References

[1] Patent: US2016/362408, 2016, A1. Location in patent: Paragraph 0455; 0456; 0457; 0458; 0459

1-Boc-3-aminoindazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-aminoindazole Suppliers

China 29 India 1 United States 2 Global 32

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1-Boc-3-aminoindazole

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1204298-58-7

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