Ethyl 2,4-dichloronicotinate
- Product Name
- Ethyl 2,4-dichloronicotinate
- CAS No.
- 62022-04-2
- Chemical Name
- Ethyl 2,4-dichloronicotinate
- Synonyms
- Ethyl 2,4-dichloronicotinate;2,4-Dichloro-nicotinic acid ethyl ester;2,4-dichloro-5-ethylpyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2,4-dichloro-, ethyl ester
- CBNumber
- CB82481371
- Molecular Formula
- C8H7Cl2NO2
- Formula Weight
- 220.05
- MOL File
- 62022-04-2.mol
Ethyl 2,4-dichloronicotinate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)6-5(9)3-4-11-7(6)10/h3-4H,2H2,1H3
- InChIKey
- KMFWUAUMIFXMBF-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(Cl)=C1C(OCC)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- E915888
- Product name
- Ethyl2,4-dichloronicotinate
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- HCH0368719
- Product name
- ETHYL-2,4-DICHLORONICOTINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.87
- Updated
- 2021/12/16
- Product number
- 047418
- Product name
- Ethyl 2,4-dichloronicotinate
- Purity
- >95%
- Packaging
- 1g
- Price
- $603
- Updated
- 2021/12/16
- Product number
- W7410
- Product name
- Ethyl2,4-dichloronicotinate
- Packaging
- 10g
- Price
- $711
- Updated
- 2021/12/16
- Product number
- 047418
- Product name
- Ethyl 2,4-dichloronicotinate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $486
- Updated
- 2021/12/16
Ethyl 2,4-dichloronicotinate Chemical Properties,Usage,Production
Synthesis
26452-80-2
62022-04-2
To a solution of tetrahydrofuran (THF, 40 mL) containing diisopropylamine (2.4 mL, 16.9 mmol) was slowly added n-butyllithium (10.6 mL, 16.9 mmol, 1.6 M hexane solution) at -78 °C and protected by an inert atmosphere and the reaction was stirred for 15 min. Maintaining the temperature at -78 °C, 2,4-dichloropyridine (1.8 mL, 16.9 mmol) was added dropwise and the reaction mixture continued to be stirred at -78 °C for 2 hours. Subsequently, ethyl cyanoformate (4.0 mL, 40.4 mmol) was added and the reaction mixture continued to be stirred at -78 °C for 1 h before slowly warming up to room temperature. The reaction mixture was partitioned with water and ethyl acetate to separate the organic layer. The organic layer was washed sequentially with saturated sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography (solid phase extraction on silica gel, gradient elution with pentane:ether from 1:0 to 4:1) to afford ethyl 2,4-dichloronicotinate as a colorless oil (1.6 g, 43% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 8.34 (1H, d, J = 5.4 Hz), 7.33 (1H, d, J = 5.4 Hz), 4.49 (2H, q, J = 7.1 Hz), 1.43 (3H, t, J = 7.1 Hz).
References
[1] Patent: WO2008/24725, 2008, A1. Location in patent: Page/Page column 106-107
Ethyl 2,4-dichloronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2,4-dichloronicotinate manufacturers
- Product
- Ethyl 2,4-dichloronicotinate 62022-04-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14