5-pyrimidineethanol

Product Name: 5-pyrimidineethanol
CAS No.: 875251-47-1
Chemical Name: 5-pyrimidineethanol
Synonyms: 2-(Pyrimidin-5-yl);5-pyrimidineethanol;2-(pyriMidin-5-yl)ethanol;2-(pyriMidin-5-yl)ethan-1-ol;5-pyrimidineethanol ISO 9001：2015 REACH
CBNumber: CB82484529
Molecular Formula: C6H8N2O
Formula Weight: 124.14
MOL File: 875251-47-1.mol

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5-pyrimidineethanol Property

Boiling point:: 252℃
Density: 1.168
Flash point:: 106℃
storage temp.: Sealed in dry,Room Temperature
pka: 14.50±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B526268
Product name: 2-(pyrimidin-5-yl)ethanol
Packaging: 25mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: W8980
Product name: 5-Pyrimidineethanol
Packaging: 250mg
Price: $477
Updated: 2021/12/16

Matrix Scientific

Product number: 089773
Product name: 2-(Pyrimidin-5-yl)ethanol
Purity: 95+%
Packaging: 250mg
Price: $515
Updated: 2021/12/16

Matrix Scientific

Product number: 089773
Product name: 2-(Pyrimidin-5-yl)ethanol
Purity: 95+%
Packaging: 1g
Price: $1143
Updated: 2021/12/16

Chemenu

Product number: CM116055
Product name: 5-Pyrimidineethanol
Purity: 98%
Packaging: 5g
Price: $1571
Updated: 2021/12/16

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5-pyrimidineethanol Chemical Properties,Usage,Production

Synthesis

6214-48-8

875251-47-1

Ethyl 2-(pyrimidin-5-yl)acetate (200 mg, 1.20 mmol) was dissolved in ethanol (15 mL) under argon protection and stirred at 0 °C. Sodium borohydride (91 mg, 2.40 mmol) was slowly added, followed by warming the reaction system to room temperature and continuous stirring for 16 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with ice water (2 mL), followed by removal of the volatile solvent under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with an eluent of 4% methanol/dichloromethane (v/v) to afford 2-(pyrimidin-5-yl)ethanol (45 mg, 30% yield) as a colorless slurry. The product was confirmed by 1H-NMR (DMSO-d6, 500 MHz): δ 9.01 (s, 1H), 8.62 (s, 2H), 4.76 (t, 1H), 3.66-3.64 (m, 2H), 2.78-2.76 (t, 2H).The LC-MS analysis showed a purity of 98.71% with a molecular ion peak of 125 (M++1). The chromatographic conditions: the column was Eclipse XDB C-18 (150×4.6 mm, 5 μm), the mobile phase was 0.05% aqueous trifluoroacetic acid: acetonitrile at a flow rate of 1.0 mL/min, and the retention time was 3.75 min. The purity of UPLC analysis was 96.67%, and the chromatographic conditions: the column was Acquity UPLC HSS T3 (2.1×100 mm. 1.8 μm), mobile phase: acetonitrile: 0.025% trifluoroacetic acid aqueous solution, flow rate 0.3 mL/min, retention time 1.86 min (IP12060040).TLC conditions: 10% methanol/dichloromethane (v/v), Rf value was 0.4. The purity of UPLC analysis was 96.67%.

References

[1] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0712; 0713; 0714

5-pyrimidineethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-pyrimidineethanol Suppliers

Austria 1 China 44 France 1 Germany 2 India 1 Ukraine 1 United States 5 Global 55

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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ProdList: 10186
Advantage: 62

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Heterochem

Tel: 027-88041443 13072715837
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Country: China
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NovoChemy Ltd.

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Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
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Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai Yolne Chemical Co., Ltd.

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Country: China
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Chemwill Asia Co.,Ltd.

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Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
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Country: China
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Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
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Email: sales@hcshhai.com
Country: China
ProdList: 9793
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View Lastest Price from 5-pyrimidineethanol manufacturers

Dideu Industries Group Limited

Product: 5-pyrimidineethanol 875251-47-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-16

Career Henan Chemical Co

Product: 5-pyrimidineethanol 875251-47-1
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: ask
Release date: 2019-12-24

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