ChemicalBook > CAS DataBase List > 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

Product Name
3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
CAS No.
395104-30-0
Chemical Name
3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
Synonyms
CC-401;CS-400;JNK-401);CC-401 (HCl);CC-401, >=98%;CC-401 (CC401;1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene;3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole;3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole;3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
CBNumber
CB82484877
Molecular Formula
C22H24N6O
Formula Weight
388.47
MOL File
395104-30-0.mol
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3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Property

Boiling point:
681.5±65.0 °C(Predicted)
Density 
1.275
storage temp. 
Store at -20°C
solubility 
≥19.4 mg/mL in DMSO; ≥2.32 mg/mL in EtOH with ultrasonic; ≥8.7 mg/mL in H2O
form 
solid
pka
9.44±0.20(Predicted)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18867
Product name
CC-401
Purity
≥98%
Packaging
5mg
Price
$467
Updated
2024/03/01
Cayman Chemical
Product number
18867
Product name
CC-401
Purity
≥98%
Packaging
10mg
Price
$826
Updated
2024/03/01
Cayman Chemical
Product number
18867
Product name
CC-401
Purity
≥98%
Packaging
1mg
Price
$106
Updated
2024/03/01
TRC
Product number
C227860
Product name
CC-401
Packaging
5mg
Price
$370
Updated
2021/12/16
ApexBio Technology
Product number
B1260
Product name
CC-401
Packaging
10mg
Price
$251
Updated
2021/12/16
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3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Chemical Properties,Usage,Production

Description

c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. CC-401 is a potent inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM). It has at least 40-fold selectivity for JNK compared with other related kinases. CC-401 is bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model. It also has been shown to decrease hepatic necrosis and apoptosis after orthotopic liver transplantation and prevent acute renal failure following ischemia/reperfusion associated with renal transplantation in rats.

Uses

CC-401 inhibits c-JUN N-terminal kinases (JNKs) by binding to its ATP-binding site. JNKs belong to the MAP kinase family and respond to stress signals such as heat, cytokines, and osmotic shock.

Definition

ChEBI: 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole is a member of pyrazoles and a ring assembly.

References

[1] ma f y, flanc r s, tesch g h, et al. a pathogenic role for c-jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. journal of the american society of nephrology, 2007, 18(2): 472-484.
[2] flanc r s, ma f y, tesch g h, et al. a pathogenic role for jnk signaling in experimental anti-gbm glomerulonephritis. kidney international, 2007, 72(6): 698-708.
[3] bogoyevitch m a, arthur p g. inhibitors of c-jun n-terminal kinases—junk no more biochimica et biophysica acta (bba)-proteins and proteomics, 2008, 1784(1): 76-93.

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Suppliers

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View Lastest Price from 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole manufacturers

Career Henan Chemical Co
Product
3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole 395104-30-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-31

395104-30-0, 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazoleRelated Search:

Acetyl chloride

  • 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
  • CC-401
  • CC-401 (HCl)
  • 1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene
  • CC-401 (CC401
  • JNK-401)
  • CS-400
  • 3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole
  • CC4013-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
  • CC-401, >=98%
  • 3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
  • 1H-Indazole, 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-
  • 395104-30-0