1-Boc-3-bromo-5-azaindole
- Product Name
- 1-Boc-3-bromo-5-azaindole
- CAS No.
- 192189-16-5
- Chemical Name
- 1-Boc-3-bromo-5-azaindole
- Synonyms
- 3-Bromo-1-Boc-5-azaindole;1-Boc-3-bromo-5-azaindole;tert-butyl 3-bromopyrrolo[3,2-c]pyridine-1-carboxylate;tert-butyl 3-bromo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 3-bromo-, 1,1-dimethylethyl ester
- CBNumber
- CB82485425
- Molecular Formula
- C12H13BrN2O2
- Formula Weight
- 297.15
- MOL File
- 192189-16-5.mol
1-Boc-3-bromo-5-azaindole Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T135870
- Product name
- tert-Butyl3-Bromo-1H-pyrrolo[3,2-C]pyridine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T135870
- Product name
- tert-Butyl3-Bromo-1H-pyrrolo[3,2-C]pyridine-1-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T135870
- Product name
- tert-Butyl3-Bromo-1H-pyrrolo[3,2-C]pyridine-1-carboxylate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 4842DN
- Product name
- Tert-Butyl3-bromo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
- Packaging
- 100mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 4H56-9-3E
- Product name
- tert-Butyl 3-bromo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $238
- Updated
- 2021/12/16
1-Boc-3-bromo-5-azaindole Chemical Properties,Usage,Production
Synthesis
24424-99-5
23612-36-4
192189-16-5
3.5601 g (18.06 mmol) of 3-bromo-1H-pyrrolo[3,2-c]pyridine and 0.4651 g (3.8 mmol, 21 mol%) of dimethylaminopyridine (DMAP) were dissolved in 80 mL of tetrahydrofuran (THF), and the solution was transferred to a 250 mL three-necked round-bottomed flask. The flask was equipped with a magnetic stirrer, thermocouple, nitrogen inlet and outlet and an ice bath cooling device. At 17 °C, 4.7769 g (21.88 mmol, 1.2 eq.) of di-tert-butyl dicarbonate (Boc2O) was slowly added to the reaction system, and the reaction mixture was continuously stirred until 3-bromo-1H-pyrrolo[3,2-c]pyridine was completely disappeared, and the progress of the reaction was monitored by thin-layer chromatography (TLC) (usually overnight with stirring at room temperature). Upon completion of the reaction, the resulting yellow solution was concentrated on a rotary evaporator and subsequently washed with 100 mL of saturated sodium bicarbonate solution and extracted with dichloromethane (3 x 80 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated again on a rotary evaporator to give 6.57 g of orange solid crude product. The crude product was purified by a CombiFlash fast chromatography system using hexane/ethyl acetate as eluent, resulting in 5.25 g (97% yield) of 3-bromo-1H-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester as a white solid.
References
[1] Patent: WO2010/33981, 2010, A2. Location in patent: Page/Page column 28
[2] Patent: WO2011/113798, 2011, A2. Location in patent: Page/Page column 35
[3] Patent: US2013/102587, 2013, A1. Location in patent: Paragraph 0183; 0184
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 15, p. 2430 - 2433
1-Boc-3-bromo-5-azaindole Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-3-bromo-5-azaindole Suppliers
- Tel
- 027-86697669 13986148687
- Fax
- 86-027-86697669
- sales@tcaschem.com
- Country
- China
- ProdList
- 4134
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 18621295758
- Fax
- -QQ:1449085402
- 1449085402@qq.com
- Country
- China
- ProdList
- 1817
- Advantage
- 55
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9717
- Advantage
- 58
- Tel
- +1-858-6993322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
- Country
- United States
- ProdList
- 21193
- Advantage
- 58