2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Product Name
- 2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- CAS No.
- 1060816-67-2
- Chemical Name
- 2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Synonyms
- 2-Chloro-7-Methyl-7H-pyrr...;2-Chloro-7-methyl-pyrrolo[2,3-d]pyrimidine;2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 2-chloro-7-methyl-
- CBNumber
- CB82485470
- Molecular Formula
- C7H6ClN3
- Formula Weight
- 167.6
- MOL File
- 1060816-67-2.mol
2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine Property
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.16±0.30(Predicted)
- form
- solid
- color
- Light yellow
Safety
- RIDADR
- UN2811
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368578
- Product name
- 2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C368578
- Product name
- 2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C368578
- Product name
- 2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 3H32-5-B3
- Product name
- 2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- Z3851
- Product name
- 2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 5g
- Price
- $365
- Updated
- 2021/12/16
2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
335654-06-3
74-88-4
1060816-67-2
Step-1: 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine (1 g, 6.5 mmol) was dissolved in acetonitrile (25 mL) at 5°C and sodium hydride (313 mg, 7.8 mmol) was added under stirring. The reaction mixture was warmed to room temperature and stirring was continued for 30 minutes. Subsequently, iodomethane was slowly added at 0 °C and then the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with acetonitrile (10 mL). The filtrate was concentrated and a portion of the product was obtained by recrystallization from ether. The mother liquor was further concentrated and purified by ISCO system (silica gel column, eluent: dichloromethane/ethyl acetate, 0 to 30% gradient). Combining the recrystallized and column chromatography-purified products, 2-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (835 mg, 77% yield) was finally obtained.
References
[1] Patent: WO2016/171755, 2016, A1. Location in patent: Paragraph 0182
[2] Patent: US2010/298334, 2010, A1. Location in patent: Page/Page column 44
[3] Patent: WO2014/100695, 2014, A1. Location in patent: Paragraph 00378
2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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