ChemicalBook > CAS DataBase List > 2-Amino-4,6-dichloro-nicotinicacidmethylester

2-Amino-4,6-dichloro-nicotinicacidmethylester

Product Name
2-Amino-4,6-dichloro-nicotinicacidmethylester
CAS No.
1044872-40-3
Chemical Name
2-Amino-4,6-dichloro-nicotinicacidmethylester
Synonyms
3-Pyri;2-amino-4,6-dichloro-, methyl ester;Methyl 2-aMino-4,6-dichloronicotinate;2-Amino-4,6-dichloro-nicotinicacidmethylester;Methyl 2-amino-4,6-dichloropyridine-3-carboxylate;2-Amino-4,6-dichloropyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylicacid, 2-amino-4,6-dichloro-, methyl ester;3-pyridinecarboxylic acid, 2-amino-4,6-dichloro-, methyl ester;3-Pyridinecarboxylicacid, 2-amino-4,6-dichloro-, methyl este...
CBNumber
CB82489645
Molecular Formula
C7H6Cl2N2O2
Formula Weight
221.04
MOL File
1044872-40-3.mol
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2-Amino-4,6-dichloro-nicotinicacidmethylester Property

Boiling point:
319.1±37.0 °C(Predicted)
Density 
1.506
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-0.40±0.50(Predicted)
Appearance
Light yellow to orange Solid
InChI
InChI=1S/C7H6Cl2N2O2/c1-13-7(12)5-3(8)2-4(9)11-6(5)10/h2H,1H3,(H2,10,11)
InChIKey
HJZKXHRUERDKKA-UHFFFAOYSA-N
SMILES
C1(N)=NC(Cl)=CC(Cl)=C1C(OC)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
Z3840
Product name
Methyl2-amino-4,6-dichloronicotinate
Packaging
250mg
Price
$131
Updated
2021/12/16
Matrix Scientific
Product number
089699
Product name
Methyl 2-amino-4,6-dichloronicotinate
Purity
95+%
Packaging
250mg
Price
$189
Updated
2021/12/16
Matrix Scientific
Product number
089699
Product name
Methyl 2-amino-4,6-dichloronicotinate
Purity
95+%
Packaging
1g
Price
$420
Updated
2021/12/16
AK Scientific
Product number
Z3840
Product name
Methyl2-amino-4,6-dichloronicotinate
Packaging
5g
Price
$451
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0049877
Product name
2-AMINO-4,6-DICHLORO-NICOTINIC ACID METHYL ESTER
Purity
95.00%
Packaging
1G
Price
$1030.84
Updated
2021/12/16
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2-Amino-4,6-dichloro-nicotinicacidmethylester Chemical Properties,Usage,Production

Uses

Methyl 2-Amino-4,6-dichloropyridine-3-carboxylate is used in preparation of macrocyclic broad spectrum antibiotics.

Synthesis

523992-26-9

1044872-40-3

The general procedure for the synthesis of methyl 2-amino-4,6-dihydroxynicotinate from methyl 2-amino-4,6-dihydroxynicotinate is as follows: Step 116-2: Methyl 2-amino-4,6-dihydroxynicotinate (30 g), phosphorochloridic acid (150 ml) and N,N-diisopropylethylamine (30 ml) obtained in step 116-1 were mixed and the mixture was stirred at room temperature for 3 days. Upon completion of the reaction, the reaction mixture was concentrated, followed by azeotropic distillation with toluene 3 times to remove residual water. Methanol (30 ml) and water (150 ml) were slowly added to the residue under cooling in an ice bath and the mixture was continued to be stirred at room temperature for 1 hour. The resulting solid was collected by filtration and this solid was combined with the solid precipitated from the filtrate. Methanol (50 ml) was added to the combined solids and after stirring for 1 hour at room temperature, the solids were collected by filtration to give primary crystals. The filtrate was concentrated, methanol (10 ml) was added to the residue and the solid was again collected by filtration to obtain secondary crystals. Finally, the primary and secondary crystals were combined to afford the target compound methyl 2-amino-4,6-dichloronicotinate (21 g, 59% yield). 1H-NMR (DMSO-D6) δ: 3.84 (s, 3H), 6.84 (s, 1H), 7.16 (br s, 2H).

References

[1] Patent: US2011/77267, 2011, A1. Location in patent: Page/Page column 48
[2] Patent: US2008/188467, 2008, A1. Location in patent: Page/Page column 48
[3] Patent: WO2015/103355, 2015, A1. Location in patent: Paragraph 0213

2-Amino-4,6-dichloro-nicotinicacidmethylester Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4,6-dichloro-nicotinicacidmethylester Suppliers

China 116 Germany 1 India 5 United Kingdom 1 United States 5 Global 128
Shandong Meiao Huawei Technology Co., LTD
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0531-88682301 18595278766
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China
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Hangzhou Chemtrue Bio-Tech Co.,Ltd.
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0571-86828652 18857119830
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China
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010-68862197 13810598707
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Energy Chemical
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Shanghai Longsheng chemical Co.,Ltd.
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EnciPharmatech Co., Ltd
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China
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China Langchem Inc.
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0086-21-58956006
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0086-21-58956100
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China
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Hangzhou Yuhao Chemical Technology Co., Ltd
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View Lastest Price from 2-Amino-4,6-dichloro-nicotinicacidmethylester manufacturers

Hangzhou ICH Biofarm Co., Ltd
Product
2-Amino-4,6-dichloro-nicotinicacidmethylester 1044872-40-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
20 tons
Release date
2023-06-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-amino-4,6-dichloro-nicotinic acid methyl ester 1044872-40-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-amino-4,6-dichloro-nicotinic acid methyl ester 1044872-40-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

1044872-40-3, 2-Amino-4,6-dichloro-nicotinicacidmethylesterRelated Search:


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