methyl 2-bromobenzo[d]thiazole-6-carboxylate
- Product Name
- methyl 2-bromobenzo[d]thiazole-6-carboxylate
- CAS No.
- 1024583-33-2
- Chemical Name
- methyl 2-bromobenzo[d]thiazole-6-carboxylate
- Synonyms
- 2-bromobenzo[d]thiazole-6-carboxylate;Methyl 2-bromobenzo[d]thiazole-6-carboxylat;methyl 2-bromobenzo[d]thiazole-6-carboxylate;methyl 2-bromo-1,3-benzothiazole-6-carboxylate;2-BroMo-benzothiazole-6-carboxylic acid Methyl ester;6-Benzothiazolecarboxylic acid, 2-bromo-, methyl ester
- CBNumber
- CB82489812
- Molecular Formula
- C9H6BrNO2S
- Formula Weight
- 272.12
- MOL File
- 1024583-33-2.mol
methyl 2-bromobenzo[d]thiazole-6-carboxylate Property
- Boiling point:
- 367.2±34.0 °C(Predicted)
- Density
- 1.697
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.43±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C9H6BrNO2S/c1-13-8(12)5-2-3-6-7(4-5)14-9(10)11-6/h2-4H,1H3
- InChIKey
- XYBYYJDNPLGJSA-UHFFFAOYSA-N
- SMILES
- S1C2=CC(C(OC)=O)=CC=C2N=C1Br
N-Bromosuccinimide Price
- Product number
- M295533
- Product name
- Methyl2-bromobenzo[d]thiazole-6-carboxylate
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 076317
- Product name
- Methyl 2-bromobenzo[d]thiazole-6-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
- Product number
- 076317
- Product name
- Methyl 2-bromobenzo[d]thiazole-6-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- X8617
- Product name
- Methyl2-bromobenzo[d]thiazole-6-carboxylate
- Packaging
- 10g
- Price
- $770
- Updated
- 2021/12/16
- Product number
- HCH0050089
- Product name
- METHYL 2-BROMOBENZO[D]THIAZOLE-6-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $831.6
- Updated
- 2021/12/16
methyl 2-bromobenzo[d]thiazole-6-carboxylate Chemical Properties,Usage,Production
Synthesis
66947-92-0
1024583-33-2
General procedure for the synthesis of methyl 2-bromobenzothiazole-6-carboxylate from methyl 2-aminobenzothiazole-6-carboxylate: to a solution of methyl 2-aminobenzothiazole-6-carboxylate (1.11 g, 5 mmol) and copper(II) bromide (2.23 g, 10 mmol) in acetonitrile (50 mL) was added slowly at 0 °C tert-butyl nitrite (1.32 mL, 10 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was extracted with ethyl acetate. The organic phase was washed sequentially with saturated sodium bicarbonate solution and brine. The solvent was removed by concentration under reduced pressure and the crude product was purified by fast column chromatography (eluent: hexane/ethyl acetate, 10:1, v/v) to afford methyl 2-bromobenzothiazole-6-carboxylate. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.53 (d, 1H), 8.15 (dd, 1H), 8.01 (d, 1H), 4.42 (q, 2H), 1.42 (t, 3H). Mass spectrum (ESI) m/z: 271.9 ([M + H]+).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 7, p. 2324 - 2328
[2] Patent: WO2008/124393, 2008, A1. Location in patent: Page/Page column 33-34
[3] Patent: WO2018/39386, 2018, A1. Location in patent: Page/Page column 138; 139
[4] Patent: US2014/200215, 2014, A1. Location in patent: Paragraph 0984; 0986
methyl 2-bromobenzo[d]thiazole-6-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 2-bromobenzo[d]thiazole-6-carboxylate Suppliers
- Tel
- 13524761129
- 2183470029@qq.com
- Country
- China
- ProdList
- 864
- Advantage
- 58
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 0531-88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 18049974220
- Fax
- +86 (21) 51062076
- 3060526242@qq.com
- Country
- China
- ProdList
- 995
- Advantage
- 60
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3991
- Advantage
- 55
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58