5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
- Product Name
- 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
- CAS No.
- 1111638-02-8
- Chemical Name
- 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
- Synonyms
- 2-Methyl-5-bromo-7-azaindole;5-Bromo-2-methyl-7-Azaind...;5-Bromo-2-methyl-7-Azaindole;5-Bromo-2-iodo-1H-pyrrolo[2,3-b]pyridine;5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-broMo-2-Methyl-
- CBNumber
- CB82489968
- Molecular Formula
- C8H7BrN2
- Formula Weight
- 211.06
- MOL File
- 1111638-02-8.mol
5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Property
- Density
- 1.654
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.49±0.40(Predicted)
- form
- powder
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- ADE001093
- Product name
- 5-Bromo-2-iodo-1H-pyrrolo[2,3-b]pyridine
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 1 g
- Price
- $1030
- Updated
- 2025/07/31
- Product number
- ADE001092
- Product name
- 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $1030
- Updated
- 2025/07/31
- Product number
- B697663
- Product name
- 5-Bromo-2-methyl-1h-pyrrolo[2,3-b]pyridine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 059416
- Product name
- 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 059416
- Product name
- 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 500mg
- Price
- $205
- Updated
- 2021/12/16
5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Chemical Properties,Usage,Production
Synthesis
1111638-01-7
1111638-02-8
Preparation of Method A Steps for the synthesis of intermediate 4: 5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine: Ingredient 3 (88 mg, 0.251 mmol) was dissolved in methanol (4 mL), 2 N sodium hydroxide solution (1 mL) was added, and the reaction mixture was heated and refluxed for 2 hours. After completion of the reaction, ethyl acetate was added for extraction and the organic phase was washed sequentially with 1 N sodium hydroxide solution and water. Purification by silica gel column chromatography (slow gradient elution, volume fraction of methanol in dichloromethane increased from 0% to 2%) afforded the target product 4 (40 mg, 0.19 mmol, 76% yield). Product characterization data were as follows: 1H NMR (CDCl3, 300 MHz): δ 10.26 (br s, 1H), 8.22 (d, J = 2.1 Hz, 1H), 8.92 (d, J = 2.1 Hz, 1H), 6.13 (s, 1H), 2.52 (s, 3H). MS (m/z): 210 (M + H).
References
[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 5, p. 582 - 586
[2] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 151-152
[3] Patent: WO2014/85795, 2014, A1. Location in patent: Paragraph 0394
[4] Bioorganic Chemistry, 2016, vol. 65, p. 146 - 158
[5] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 74
5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine manufacturers
- Product
- 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine 1111638-02-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08