3-Bromo-5-chlorophenylethanone
- Product Name
- 3-Bromo-5-chlorophenylethanone
- CAS No.
- 154257-85-9
- Chemical Name
- 3-Bromo-5-chlorophenylethanone
- Synonyms
- 3-Bromo-5-chloroacetophenone;3'-Bromo-5'-chloroacetophenone;3-Bromo-5-chlorophenylethanone;3-Bromo-5-chlorophenacylchloride;1-(3-Bromo-5-chlorophenyl)ethanone;(3-bromo-5-chlorophenyl)acetaldehyde;Ethanone, 1-(3-bromo-5-chlorophenyl)-;1-(3-bromo-5-chlorophenyl)ethan-1-one;1gof1-(3-bromo-5-chlorophenyl)ehtnanone
- CBNumber
- CB82490054
- Molecular Formula
- C8H6BrClO
- Formula Weight
- 233.49
- MOL File
- 154257-85-9.mol
3-Bromo-5-chlorophenylethanone Property
- Boiling point:
- 301.5±32.0 °C(Predicted)
- Density
- 1.566
- storage temp.
- Sealed in dry,Room Temperature
- form
- wooly crystalline powder
- color
- Faint lemon
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0361853
- Product name
- 1-(3-BROMO-5-CHLOROPHENYL)ETHANONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $409.5
- Updated
- 2021/12/16
- Product number
- 7744AA
- Product name
- 1-(3-Bromo-5-chlorophenyl)ethanone
- Packaging
- 5g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- OR400317
- Product name
- 3'-Bromo-5'-chloroacetophenone
- Packaging
- 5g
- Price
- $667
- Updated
- 2021/12/16
- Product number
- 2617-D-10
- Product name
- 3'-Bromo-5'-chloroacetophenone
- Packaging
- 5G
- Price
- $736
- Updated
- 2021/12/16
- Product number
- OR400317
- Product name
- 3'-Bromo-5'-chloroacetophenone
- Packaging
- 1g
- Price
- $182
- Updated
- 2021/12/16
3-Bromo-5-chlorophenylethanone Chemical Properties,Usage,Production
Synthesis
14862-52-3
78191-00-1
154257-85-9
Example 26: Preparation of 1-(3-bromo-5-chlorophenyl)ethan-1-one (C148) (0740) (0741) 1,3-Dibromo-5-chlorobenzene (5.0 g, 18.5 mmol) was dissolved in diethyl ether (61.6 mL) and the solution was cooled to -78°C. After the compound was observed to precipitate from the solution, the mixture was removed from the cooling bath. When the temperature returned to a stir-able state, n-butyllithium (8.14 mL, 20.34 mmol) was added dropwise, followed by immersing the solution into the cooling bath again. The solution took on a bright yellow color and stirring of the mixture was continued for 30 minutes. At this point a slight yellow precipitate was seen to form. N-methoxy-N-methylacetamide (2.359 mL, 22.19 mmol) was added dropwise and the reaction mixture was stirred for 10 minutes before slowly warming to room temperature. The reaction mixture was quenched with 1N hydrochloric acid and subsequently extracted with ether. The organic extracts were combined, washed with brine, dried over sodium sulfate and concentrated. The resulting oil was purified by silica gel column chromatography using a gradient elution with a hexane solution of 0-15% acetone. Final isolation afforded 3-bromo-5-chloroacetophenone as a white solid (3.7 g, 86% yield): melting point 33-36 °C. The product was purified by silica gel chromatography. 1H NMR (300 MHz, CDCl3) δ 7.97-7.95 (m, 1H), 7.85 (dd, J = 1.5 Hz, 1H), 7.71 (t, J = 1.8 Hz, 1H), 2.59 (s, 3H); IR (thin film) 1687 cm-1; ESIMS m/z 233 ([M + H]+).
References
[1] Patent: US2017/208806, 2017, A1. Location in patent: Paragraph 0740; 0741
[2] Patent: WO2014/15054, 2014, A1. Location in patent: Page/Page column 193
3-Bromo-5-chlorophenylethanone Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-5-chlorophenylethanone Suppliers
- Tel
- --
- Fax
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
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- 6084
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View Lastest Price from 3-Bromo-5-chlorophenylethanone manufacturers
- Product
- 3-Bromo-5-chlorophenylethanone 154257-85-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-05
- Product
- 3-Bromo-5-chlorophenylethanone 154257-85-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-02
- Product
- 3-Bromo-5-chlorophenylethanone 154257-85-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-23