ChemicalBook > CAS DataBase List > 2-Bromo-4,5-difluorobenzaldehyde

2-Bromo-4,5-difluorobenzaldehyde

Product Name: 2-Bromo-4,5-difluorobenzaldehyde
CAS No.: 476620-54-9
Chemical Name: 2-Bromo-4,5-difluorobenzaldehyde
Synonyms: 5-difluorobenzaldehyde;2-Bromo-4,5-difluorobenzaldehyde;Benzaldehyde, 2-bromo-4,5-difluoro-;2-Bromo-4,5-difluorobenzaldehyde,98%;2-Bromo-4,5-difluorobenzaldehyde ISO 9001：2015 REACH
CBNumber: CB82490913
Molecular Formula: C7H3BrF2O
Formula Weight: 221
MOL File: 476620-54-9.mol

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2-Bromo-4,5-difluorobenzaldehyde Property

Boiling point:: 232.0±35.0 °C(Predicted)
Density: 1.758±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
form: Powder
color: Off-white
Water Solubility: Slightly soluble in water.

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Safety

HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B997240
Product name: 2-Bromo-4,5-difluorobenzaldehyde
Packaging: 50mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2615-B-X8
Product name: 2-Bromo-4,5-difluorobenzaldehyde
Packaging: 100mg
Price: $67
Updated: 2021/12/16

Matrix Scientific

Product number: 100605
Product name: 2-Bromo-4,5-difluorobenzaldehyde
Purity: 95+%
Packaging: 250mg
Price: $19
Updated: 2021/12/16

AK Scientific

Product number: V6104
Product name: 2-Bromo-4,5-difluorobenzaldehyde
Packaging: 250mg
Price: $23
Updated: 2021/12/16

Matrix Scientific

Product number: 100605
Product name: 2-Bromo-4,5-difluorobenzaldehyde
Purity: 95+%
Packaging: 500mg
Price: $29
Updated: 2021/12/16

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2-Bromo-4,5-difluorobenzaldehyde Chemical Properties,Usage,Production

Uses

It is an important intermediate for pharmaceutical and organic synthesis.

Synthesis

476620-55-0

476620-54-9

General procedure for the synthesis of 2-bromo-4,5-difluorobenzaldehyde from (2-bromo-4,5-difluorophenyl)methanol: (2-bromo-4,5-difluorophenyl)methanol (1.23 g, 5.50 mmol), triethylamine (1.39 g, 13.75 mmol) and dimethylsulfoxide (1.72 g, 22.00 mmol) were dissolved in dichloromethane (25 mL) in dichloromethane (25 mL) and cooled to 0°C. Subsequently, sulfur trioxide-pyridine complex (1.32 g, 8.25 mmol) was added in batches. The reaction mixture was stirred at 0 °C for 1 h. Triethylamine (1.39 g, 13.75 mmol), dimethyl sulfoxide (1.72 g, 22.00 mmol) and sulfur trioxide-pyridine complex (1.32 g, 8.25 mmol) were added again. After continued stirring at 0 °C for 30 min, the reaction solution was diluted with dichloromethane (50 mL) and washed sequentially with saturated sodium bicarbonate solution and saturated sodium thiosulfate solution. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography (RediSep fast column, 230-400 mesh silica gel, eluent 10-30% ethyl acetate in hexane solution) afforded 2-bromo-4,5-difluorobenzaldehyde (0.47 g, 39% yield).1H NMR (300 MHz, CDCl3) δ 10.23 (s, 1H), 7.77 (m, 1H), 7.52 (m, 1H).

References

[1] Patent: WO2010/55005, 2010, A1. Location in patent: Page/Page column 70-71
[2] Patent: WO2011/20193, 2011, A1. Location in patent: Page/Page column 18-19
[3] Patent: WO2011/57382, 2011, A1. Location in patent: Page/Page column 21
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1953 - 1957

2-Bromo-4,5-difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-4,5-difluorobenzaldehyde manufacturers

Career Henan Chemical Co

Product: 2-Bromo-4,5-difluorobenzaldehyde 476620-54-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-17

476620-54-9, 2-Bromo-4,5-difluorobenzaldehydeRelated Search:

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476620-54-9