2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine
- Product Name
- 2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine
- CAS No.
- 1104027-46-4
- Chemical Name
- 2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine
- Synonyms
- 2-benzyl-5-chloro-3,4-dihydro-1H-2,6-naphthyridine;2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine;5-Chloro-1,2,3,4-tetrahydro-2-(benzyl)-2,6-naphthyridine;5-Chloro-1,2,3,4-tetrahydro-2-(phenylmethyl)-2,6-naphthyridine;2,6-Naphthyridine, 5-chloro-1,2,3,4-tetrahydro-2-(phenylmethyl)-;2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine hydrochloride;2,6-Naphthyridine-2(1H)-carboxylic acid, 5-chloro-3,4-dihydro-, 1,1-dimethylethyl ester
- CBNumber
- CB82499244
- Molecular Formula
- C15H15ClN2
- Formula Weight
- 258.75
- MOL File
- 1104027-46-4.mol
2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine Property
- Boiling point:
- 377.5±42.0 °C(Predicted)
- Density
- 1.227
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 5.38±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C386010
- Product name
- 5-Chloro-1,2,3,4-tetrahydro-2-(phenylmethyl)-2,6-naphthyridine
- Packaging
- 500mg
- Price
- $920
- Updated
- 2021/12/16
- Product number
- 070281
- Product name
- 2-Benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $1172
- Updated
- 2021/12/16
- Product number
- X8937
- Product name
- 2-Benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine
- Packaging
- 1g
- Price
- $1519
- Updated
- 2021/12/16
- Product number
- 070281
- Product name
- 2-Benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $3885
- Updated
- 2021/12/16
- Product number
- HCH0363042
- Product name
- 2-BENZYL-5-CHLORO-1,2,3,4-TETRAHYDRO-2,6-NAPHTHYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.43
- Updated
- 2021/12/16
2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine Chemical Properties,Usage,Production
Uses
5-Chloro-1,2,3,4-tetrahydro-2-(phenylmethyl)-2,6-naphthyridine is an intermediate used to prepare substituted naphthyridines as FAAH modulators useful in prevention and treatment of FAAH-mediated diseases.
Synthesis
A round bottom flask was charged with 6-benzyl-5,6,7,8-tetrahydro-2,6-naphthyridin-1-ol (7 g, 29 mmol) and phosphorochloridic acid {LeonidChemicals, India; add 80 mL) and heated to reflux for 16 hours to monitor the progress of the reaction by TLC. Upon completion of the reaction, POCl3 was distilled and the residue was quenched with ice-cold water and then extracted with dichloromethane (3 100 mL). The combined organic layers were dried with anhydrous sodium sulfate and the solvent was removed under reduced pressure. The residue was purified by column chromatography (methanol/dichloromethane, 5:95) to afford the desired product 2-phenylmethyl-5-chloro-1,2,3,4-tetrahydro-[2,6]diazanaphthalene (80% yield).
2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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