1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride
- Product Name
- 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride
- CAS No.
- 1121057-75-7
- Chemical Name
- 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride
- Synonyms
- "1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-;DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE;1,2,3,6-Tetrahydropyridine-4-boronic acid, pinacol ester, HCl;(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)BORONIC ACID HCL PINACOL ESTER;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetr...;1,2,3,6-Tetrahydropyridine-4-boronic acid pinacol ester hydrochl;1,2,3,6-Tetrahydropyridine-4-yl-boronic acid picol ester hydrochloride;1,2,3,6-Tetrahydropyridine-4-boronic acid, pinacolester, hydrochloride.;1,2,3,6-Tetrahydropyridine-4-yl-boronic acid pinacol ester hydrochloride;4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride
- CBNumber
- CB82499628
- Molecular Formula
- C11H21BClNO2
- Formula Weight
- 245.55
- MOL File
- 1121057-75-7.mol
1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- Appearance
- White to off-white Solid
- InChI
- 1S/C11H20BNO2.ClH/c1-10(2)11(3,4)15-12(14-10)9-5-7-13-8-6-9;/h5,13H,6-8H2,1-4H3;1H
- InChIKey
- WNMYCAJTXUCHBQ-UHFFFAOYSA-N
- SMILES
- CC(O1)(C)C(C)(C)OB1C2=CCNCC2.Cl
Safety
- WGK Germany
- WGK 3
- HS Code
- 2933399990
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- BML00286
- Product name
- 1,2,3,6-Tetrahydropyridine-4-boronic acid pinacol ester hydrochloride
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $529
- Updated
- 2026/03/19
- Product number
- T295705
- Product name
- 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridineHydrochloride
- Packaging
- 2.5g
- Price
- $545
- Updated
- 2021/12/16
- Product number
- 8H60-5-64
- Product name
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride
- Packaging
- 1g
- Price
- $568
- Updated
- 2021/12/16
- Product number
- 48883
- Product name
- 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridineHCl
- Packaging
- 1g
- Price
- $750
- Updated
- 2021/12/16
- Product number
- BOR0006727
- Product name
- 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $380.1
- Updated
- 2021/12/16
1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride Chemical Properties,Usage,Production
Uses
1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is a useful synthetic intermediate. It was used in the synthesis of N-arylheterocycles as MCH antagonists. It can also be used as a reagent to prepare substituted imidazopyridine derivatives and analogs for use as antiviral agents.
Synthesis
375853-82-0
1121057-75-7
Method 3: General conditions for deprotection of N-Boc carbamates in the presence of borate esters: 1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine was dissolved in tert-butylmethyl ether (0.4 M final ester concentration), then HCl (g) was drummed into the solution over a period of 15 min. The reaction mixture was stirred at room temperature for 1 h. Subsequent removal of the solvent under a stream of nitrogen afforded 1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester hydrochloride as a white solid in quantitative yield. Example 2: Tetrahydropyridine-4-boronic acid pinacol ester was prepared in a 3-step reaction using Method 3 starting from the deprotection of 1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine. The resulting HCl amine salt was dissolved in dichloromethane (0.2 M) and benzyl chloroformate (1.2 eq.) and triethylamine (3.0 eq.) were added sequentially. The reaction mixture was stirred at room temperature for 2 hours before being diluted with 1N HCl and extracted with excess dichloromethane. The organic layer was dried over MgSO4 and concentrated to afford the target carbamate in quantitative yield, which was subsequently converted directly to the boronic acid derivative via Method 2. [M-H] = 260.1 m/z. Activity: B
References
[1] Patent: WO2010/118159, 2010, A1. Location in patent: Page/Page column 64; 65-66
[2] Patent: WO2014/100620, 2014, A2. Location in patent: Paragraph 0318
[3] Patent: WO2015/91685, 2015, A1. Location in patent: Page/Page column 138; 139
[4] Patent: US2015/166549, 2015, A1. Location in patent: Paragraph 0858; 0859; 0860
[5] Patent: WO2011/143495, 2011, A1. Location in patent: Page/Page column 85
1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride Preparation Products And Raw materials
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View Lastest Price from 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride manufacturers
- Product
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride 1121057-75-7
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-05
- Product
- 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride 1121057-75-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-10