4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane

Product Name: 4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane
CAS No.: 879648-22-3
Chemical Name: 4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane
Synonyms: 2-(Methylsulfonyl)benzeneboronic acid pinacol ester;(2-(METHYLSULFONYL)PHENYL)BORONIC ACID PINACOL ESTER;2-(2-Methanesulfonylphenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[2-(methylsulfonyl)phenyl]-;4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane（WS202867）
CBNumber: CB82500076
Molecular Formula: C13H19BO4S
Formula Weight: 282.16
MOL File: 879648-22-3.mol

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4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-B1258
Product name: 4,4,5,5-Tetramethyl-2-[2-(methylsulfonyl)phenyl]-1,3,2-dioxaborolane
Packaging: 100mg
Price: $156
Updated: 2021/12/16

AK Scientific

Product number: 2021AQ
Product name: 4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane
Packaging: 1g
Price: $678.8
Updated: 2021/12/16

Matrix Scientific

Product number: 192327
Product name: 4,4,5,5-Tetramethyl-2-[2-(methylsulfonyl)phenyl]-1,3,2-dioxaborolane
Purity: 95%
Packaging: 5g
Price: $1486
Updated: 2021/12/16

AOBChem

Product number: 31616
Product name: 2-(Methylsulfonyl)phenylboronicacidpinacolester
Purity: 97%
Packaging: 25g
Price: $2939
Updated: 2021/12/16

A1 Biochem Labs

Product number: 6578647
Product name: 4,4,5,5-Tetramethyl-2-[2-(methylsulfonyl)phenyl]-1,3,2-dioxaborolane
Purity: 95%
Packaging: 5G
Price: $900
Updated: 2021/12/16

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4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane Chemical Properties,Usage,Production

Synthesis

33951-33-6

73183-34-3

879648-22-3

Step 1: 1-bromo-2-(methylsulfonyl)benzene (800 mg, 3.40 mmol), bis(pinacolato)diboron (1040 mg, 4.08 mmol), and potassium acetate (668 mg, 6.81 mmol) were dissolved in dioxane (4 mL) under nitrogen protection and degassed by bubbling nitrogen. Subsequently, PdCl2(dppf)-CH2Cl2 adduct (139 mg, 0.170 mmol) was added and the reaction mixture was heated to 95 °C and kept for 2 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and filtered through diatomaceous earth. The organic layer was washed with brine and dried with anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the residue was purified by silica gel column chromatography (40 g column, gradient elution: 0 to 40% ethyl acetate/hexanes) to afford 4,4,5,5-tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane (626 mg, 65% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 8.03 (dd, J = 7.6, 1.2 Hz, 1H), 7.72-7.67 (m, 1H), 7.61 (dtd, J = 18.6, 7.4, 1.5 Hz, 2H), 5.32 (s, 1H), 3.24 (s, 3H), 1.43 (s, 12H); LCMS (M + H) = 283.2; HPLC RT = 0.89 min (column: BEH C18 2.1×50 mm; mobile phase A: water containing 0.05% TFA; mobile phase B: acetonitrile containing 0.05% TFA; gradient: 2-98% B, 1.6 min; flow rate: 0.8 mL/min).

References

[1] Patent: WO2015/100282, 2015, A1. Location in patent: Page/Page column 282; 283
[2] Patent: US2016/176864, 2016, A1. Location in patent: Paragraph 0802; 0803

4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane Suppliers

China 32 India 1 United States 2 Global 35

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Jiaxing Deyi Chemical Co., Ltd.

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View Lastest Price from 4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane manufacturers

Career Henan Chemical Co

Product: 4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane 879648-22-3
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 1kg; 5kg
Release date: 2020-02-03

879648-22-3, 4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolaneRelated Search:

4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane

2-(2-Methanesulfonylphenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

(2-(METHYLSULFONYL)PHENYL)BORONIC ACID PINACOL ESTER

4,4,5,5-Tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane（WS202867）

1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[2-(methylsulfonyl)phenyl]-

2-(Methylsulfonyl)benzeneboronic acid pinacol ester

879648-22-3

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