ChemicalBook > CAS DataBase List > ADL-5859

ADL-5859

Product Name
ADL-5859
CAS No.
850173-95-4
Chemical Name
ADL-5859
Synonyms
CS-24;ADL-5859;ADL5859 HCl;ADL 5859;ADL-5859;ADL-5859 USP/EP/BP;ADL5859 HCl ，S1139;Adl59 hydrochloride;ADL5859 hydrochloride;ADL-5859, 10 mM in DMSO;ADL5859 hydrochloride hcl
CBNumber
CB82501013
Molecular Formula
C24H29ClN2O3
Formula Weight
428.95166
MOL File
850173-95-4.mol
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ADL-5859 Property

storage temp. 
Store at -20°C
solubility 
≥21.45 mg/mL in DMSO; insoluble in EtOH; ≥5.48 mg/mL in H2O with ultrasonic
form 
solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27796
Product name
ADL5859 (hydrochloride)
Packaging
25mg
Price
$773
Updated
2024/03/01
Cayman Chemical
Product number
27796
Product name
ADL5859 (hydrochloride)
Packaging
50mg
Price
$1158
Updated
2024/03/01
Cayman Chemical
Product number
27796
Product name
ADL5859 (hydrochloride)
Packaging
5mg
Price
$194
Updated
2024/03/01
Cayman Chemical
Product number
27796
Product name
ADL5859 (hydrochloride)
Packaging
10mg
Price
$348
Updated
2024/03/01
TRC
Product number
D442035
Product name
N,​N-Diethyl-​4-​(5-​hydroxyspiro[2H-​1-​benzopyran-​2,​4''-​piperidin]​-​4-​yl)​-​benzamideHydrochloride
Packaging
10mg
Price
$420
Updated
2021/12/16
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ADL-5859 Chemical Properties,Usage,Production

Uses

N,?N-Diethyl-?4-?(5-?hydroxyspiro[2H-?1-?benzopyran-?2,?4''-?piperidin]?-?4-?yl)?-?benzamide Hydrochloride is a selective δ-opioid receptor agonist. It is an analgesic and antidepressive agent and a potential drug candidate for treating chronic pain.

in vivo

ADL-5859 (0.3-10 mg/kg; p.o. once) hydrochloride reverses hyperalgesia in inflamed paw of rats and shows robust antidepressant-like activity[1].

1.19Pharmacokinetic Properties of ADL-5859 in Rats and Dogs[1].
Rats
IV 0.25 mg/kg and PO 3 mg/kg		Dogs
IV 1 mg/kg and PO 3 mg/kg
CLs (L/h/kg)1.8±0.50.4±0.1
Vdss (L/kg)10.7±1.92.5±0.5
t1/2 (oral, h)5.3±0.74.7±0.2
F (%)33.4±3.266.5±6.8
Animal Model:Rats with Freund’s Complete Adjuvant (FCA) injection induced mechanical hyperalgesia[1]
Dosage:0.3-10 mg/kg
Administration:Oral gavage; 0.3-10 mg/kg once
Result:Produced 100% reversal of hyperalgesia in the inflamed paw with a dose of 3 mg/kg and showed an oral ED50 value of 1.4 mg/kg.
Animal Model:Male Sprague-Dawley rats[1]
Dosage:0.3 and 3 mg/kg
Administration:Oral gavage; 0.3 and 3 mg/kg once
Result:Produced robust antidepressant-like activity in the rat forced swim assay with a dose of 3 mg/kg.

target

δ-opioid receptor

IC 50

δ Opioid Receptor/DOR

ADL-5859 Preparation Products And Raw materials

Raw materials

Preparation Products

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ADL-5859 Suppliers

China 94 India 1 United States 17 Global 112
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
Advantage
55
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View Lastest Price from ADL-5859 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
ADL-5859 850173-95-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

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  • CS-24
  • ADL 5859;ADL-5859
  • ADL5859 HCl
  • ADL5859 HCL;ADL5859; ADL 5859
  • ADL-5859
  • N,N-Diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)benzamide hydrochloride
  • ADL5859 hydrochloride
  • Benzamide, N,N-diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)-, hydrochloride (1:1)
  • N,N-Diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)benzamide hydrochloride ADL-5859
  • Adl59 hydrochloride
  • ADL-5859 USP/EP/BP
  • ADL5859 hydrochloride hcl
  • Benzamide, N,N-diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)-, hydrochloride
  • ADL-5859, 10 mM in DMSO
  • ADL5859 HCl ，S1139
  • 850173-95-4
  • C24H28N2O3ClH
  • δ opioid receptor agonist.
  • API
  • Inhibitors