ChemicalBook > CAS DataBase List > 4-hydroxy-2-trifluoromethylbenzaldehyde
4-hydroxy-2-trifluoromethylbenzaldehyde
- Product Name
- 4-hydroxy-2-trifluoromethylbenzaldehyde
- CAS No.
- 1243395-68-7
- Chemical Name
- 4-hydroxy-2-trifluoromethylbenzaldehyde
- Synonyms
- 95-68;4-hydroxy-2-trifluoromethylbenzaldehyde;Benzaldehyde, 4-hydroxy-2-(trifluoromethyl)-
- CBNumber
- CB82501725
- Molecular Formula
- C8H5F3O2
- Formula Weight
- 190.12
- MOL File
- 1243395-68-7.mol
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4-hydroxy-2-trifluoromethylbenzaldehyde Property
- Melting point:
- 128 - 131°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
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Safety
- HS Code
- 2913000090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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N-Bromosuccinimide Price
TRC
- Product number
- H977615
- Product name
- 4-Hydroxy-2-(trifluoromethyl)benzaldehyde
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
TRC
- Product number
- H977615
- Product name
- 4-Hydroxy-2-(trifluoromethyl)benzaldehyde
- Packaging
- 2.5g
- Price
- $275
- Updated
- 2021/12/16
AK Scientific
- Product number
- 4592AA
- Product name
- 4-Hydroxy-2-(trifluoromethyl)benzaldehyde
- Packaging
- 5g
- Price
- $370
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2815-3-0A
- Product name
- 4-Hydroxy-2-(trifluoromethyl)benzaldehyde
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 119799
- Product name
- 4-Hydroxy-2-(trifluoromethyl)benzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $270
- Updated
- 2021/12/16
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4-hydroxy-2-trifluoromethylbenzaldehyde Chemical Properties,Usage,Production
Synthesis
106312-36-1
1243395-68-7
The general procedure for the synthesis of 4-hydroxy-2-trifluoromethylbenzaldehyde using 2-trifluoromethyl-4-methoxybenzaldehyde as a starting material was as follows: boron tribromide (1.39 mL, 14.7 mmol) was dissolved in 5 mL of dichloromethane (DCM) at -78 °C and added slowly and dropwise to a 2-trifluoromethyl-4-methoxybenzaldehyde (2.0 g, 9.8 mmol) containing a 20 mL of DCM solution. The reaction mixture was stirred at room temperature for 15 hours. Upon completion of the reaction, the reaction was quenched with ice water and extracted with DCM. The organic phases were combined and washed sequentially with sodium bicarbonate solution, water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography, and the eluent was mixed solvent of petroleum ether-ethyl acetate to obtain 4-hydroxy-2-trifluoromethylbenzaldehyde as a brown liquid in 91% yield. The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 10.035 (s, 1H), 7.984-7.963 (d, 1H, J = 8.4 Hz), 7.193-7.158 (m, 2H) ppm.
References
[1] Patent: WO2010/127208, 2010, A1. Location in patent: Page/Page column 53
[2] Patent: US2014/256657, 2014, A1. Location in patent: Paragraph 0417
4-hydroxy-2-trifluoromethylbenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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