6-Bromothiochroman-4-one
- Product Name
- 6-Bromothiochroman-4-one
- CAS No.
- 13735-13-2
- Chemical Name
- 6-Bromothiochroman-4-one
- Synonyms
- 6-Bromothiochroman-4-one;6-BroMo-3,4-dihydro-2H-1-benzothiin-4-one;6-bromo-2,3-dihydro-4H-1-Benzothiopyran-4-one;4H-1-Benzothiopyran-4-one, 6-bromo-2,3-dihydro-
- CBNumber
- CB82504827
- Molecular Formula
- C9H7BrOS
- Formula Weight
- 243.12
- MOL File
- 13735-13-2.mol
6-Bromothiochroman-4-one Property
- Melting point:
- 66-69℃
- Boiling point:
- 356.7±42.0 °C(Predicted)
- Density
- 1.638±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B700803
- Product name
- 6-Bromothiochroman-4-one
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FB36091
- Product name
- 6-Bromothiochroman-4-one
- Packaging
- 2g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FB36091
- Product name
- 6-Bromothiochroman-4-one
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 8261AJ
- Product name
- 6-Bromothiochroman-4-one
- Packaging
- 5g
- Price
- $347
- Updated
- 2021/12/16
- Product number
- FB36091
- Product name
- 6-Bromothiochroman-4-one
- Packaging
- 10g
- Price
- $400
- Updated
- 2021/12/16
6-Bromothiochroman-4-one Chemical Properties,Usage,Production
Chemical Properties
Orange solid
Synthesis
3528-17-4
909248-27-7
13735-13-2
General procedure for the synthesis of 6-bromothiochroman-4-one and 6,8-dibromothiochroman-4-one from thiochroman-4-one: Anhydrous aluminum trichloride (1.81 g, 13.5 mmol) and methylene chloride (1 mL) were added to a round bottom flask at room temperature. After stirring for about 7 min under nitrogen protection, a solution of thiocolchroman-4-one (1.11 g, 6.77 mmol) in dichloromethane (1 mL) was slowly added. Stirring was continued for 10 minutes and then a solution of bromine (1.19 g, 7.44 mmol) in dichloromethane (2 mL) was added dropwise. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was poured into ice water (50 mL) and the aqueous phase was extracted with ethyl acetate three times. The organic phases were combined, washed once with saturated saline and dried over anhydrous sodium sulfate. The crude product was purified by fast column chromatography (15% ethyl acetate/85% hexane) to give a mixture of 6-bromothiochroman-4-one (0.648 g, 34% purity, 13% yield) and 6,8-dibromothiochroman-4-one (66% purity, 20% yield).The NMR data for 6,8-dibromothiochroman-4-one were as follows:1H NMR (300 MHz , CDCl3, δ): 8.18 (dd, J = 2.2, 0.7 Hz, Ar-H, 1H), 7.77 (dd, J = 2.2, 0.7 Hz, Ar-H, 1H), 3.22 (m, CH2, 2H), 2.94 (m, CH2, 2H). 13C NMR (75 MHz, CDCl3): δ 192.0, 142.5 , 139.1, 136.0, 131.0, 122.2, 118.2, 37.8, 26.0.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 16, p. 4405 - 4409
[2] Patent: US2009/76076, 2009, A1. Location in patent: Page/Page column 24
6-Bromothiochroman-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
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