7-Hydroxymitragynine

Product Name: 7-Hydroxymitragynine
CAS No.: 174418-82-7
Chemical Name: 7-Hydroxymitragynine
Synonyms: 7-Hydroxy Mitragynine;7- hydroxy-cap lignan;HYDROXYMITRAGYNINE, 7-;7α-Hydroxy-7H-Mitragynine;HYDROXYMITRAGYNINE, 7-(SH);7-Hydroxymitragynine solution;Mitragynine Hydroxyindolenine;7-Hydroxymitragynine wholesale;7-Hydroxy Mitragynine CAS 174418 82 7;9-Methoxycorynantheidine Hydroxyindolenine
CBNumber: CB82511915
Molecular Formula: C23H30N2O5
Formula Weight: 414.49
MOL File: 174418-82-7.mol

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7-Hydroxymitragynine Property

Boiling point:: 567.4±50.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
Flash point:: 2℃
storage temp.: -20°C Freezer
solubility: Ethanol: 5 mg/ml; Methanol: 10 mg/ml
form: A crystalline solid
pka: 12.20±0.60(Predicted)
InChI: InChI=1/C23H30N2O5/c1-5-14-12-25-10-9-23(27)20-17(7-6-8-19(20)29-3)24-21(23)18(25)11-15(14)16(13-28-2)22(26)30-4/h6-8,13-15,18,27H,5,9-12H2,1-4H3/b16-13+/t14-,15+,18-,23-/s3
InChIKey: RYENLSMHLCNXJT-XIYIOZPINA-N
SMILES: c1c(OC)c2[C@]3(O)CCN4C[C@@H](CC)[C@@H](/C(/C(=O)OC)=C\OC)C[C@@H]4C3=Nc2cc1 |&1:5,11,14,24,r|

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H-099
Product name: 7-Hydroxymitragynine solution
Purity: 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 13114
Product name: 7-hydroxy Mitragynine
Purity: ≥98%
Packaging: 1mg
Price: $480
Updated: 2024/03/01

TRC

Product number: H947910
Product name: 7-HydroxyMitragynine
Packaging: 2.5mg
Price: $3235
Updated: 2021/12/16

TRC

Product number: H947910
Product name: 7-HydroxyMitragynine
Packaging: 0.25mg
Price: $410
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH74974
Product name: 7-Hydroxy mitragynine
Packaging: 2mg
Price: $3400
Updated: 2021/12/16

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7-Hydroxymitragynine Chemical Properties,Usage,Production

Description

7-Hydroxymitragynine is a terpenoid indole alkaloid from the plant Mitragyna speciosa, It is a minor constituent of this plant (Ponglux et al., 1994). 7-Hydroxymitragynine exhibited a higher potency than mitragynine in the guinea-pig ileum test and a high affinity for A-opioid receptors in binding assays (Takayama et al., 2002).

Uses

A metabolite of Mitragynine. Along with mitragynine, 7-Hydroxymitragynine is an active alkaloid found in the plant Mitragynine speciosa, commonly known as Kratom. The compound possesses opioid agonistic activity with a potentcy 30- and 17-fold higher than that of mitragynine and morphine, respectively.

Preparation

7-Hydroxymitragynine is produced by oxidation of mitragynine and is a minor constituent (< 0.01% in fresh leaves) found at concentrations of up to 2% in leaf extracts and commercial kratom products; however, it is believed to be the major contributor to the known addictive potential of kratom given its activity as a potent μ-opioid receptor agonist.

Definition

ChEBI: 7-Hydroxymitragynine is an alkaloid.

Pharmacokinetics

Mitragynine and 7-hydroxymitragynine are partial agonists at the mu-opioid receptor. Human studies demonstrate the analgesic effects of kratom, while kratom extract, mitragynine and 7-hydroxymitragynine have been shown to be antinociceptive in animal models. The antinociceptive effects are reversed by an opioid antagonist.
Mitragynine also binds to adrenergic receptors, serotonergic and dopamine receptors. Although there is limited information regarding its effects at these receptors, kratom extracts and mitragynine have been reported in animal studies to have a variety of non-opioid-like behavioural effects, including antidepressant and antipsychotic effects.

7-Hydroxymitragynine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Hydroxymitragynine Suppliers

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View Lastest Price from 7-Hydroxymitragynine manufacturers

ARCTIC EXPORTS INC

Product: 7-Hydroxymitragynine 174418-82-7
Price: US $1.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-05-10

ARCTIC EXPORTS INC

Product: 7-Hydroxymitragynine wholesale 174418-82-7
Price: US $1.00-1.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-03-19

174418-82-7, 7-HydroxymitragynineRelated Search:

7-Hydroxy Mitragynine

(7α,16E,20β)- 1,2,16,17-Tetradehydro-2,7-dihydro-7-hydroxy-9,17-diMethoxycorynan-16-carboxylic acid Methyl Ester

(αE,2S,3S,7aS,12bS)-3-Ethyl-1,2,3,4,6,7,7a,12b-octahydro-7a-hydroxy-8-Methoxy-α-(MethoxyMethylene)indolo[2,3-a]quinolizine-2-acetic Acid Methyl Ester

7α-Hydroxy-7H-Mitragynine

9-Methoxycorynantheidine Hydroxyindolenine

Mitragynine Hydroxyindolenine

HYDROXYMITRAGYNINE, 7-(SH)

7-Hydroxymitragynine solution

7-Hydroxy Mitragynine (100 μg/mL in 0.1 N Ammonia in Methanol)

Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethyl-1,2,3,4,6,7,7a,12b-octahydro-7a-hydroxy-8-methoxy-α-(methoxymethylene)-, methyl ester, (αE,2S,3S,7aS,12bS)-

7-Hydroxy Mitragynine CAS 174418 82 7

methyl (E)-2-[(2S,3S,7aS,12bS)-3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate

7- hydroxy-cap lignan

HYDROXYMITRAGYNINE, 7-

7-Hydroxymitragynine wholesale

174418-82-7

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