2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

Product Name: 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride
CAS No.: 1208901-69-2
Chemical Name: 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride
Synonyms: 2,4-Dichloro-5,6,7,8-tetrahyd;2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE HCL;2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine hydrochloride
CBNumber: CB82513777
Molecular Formula: C7H8Cl3N3
Formula Weight: 240.51752
MOL File: 1208901-69-2.mol

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2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride Property

storage temp.: 2-8°C(protect from light)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D438230
Product name: 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHydrochloride
Packaging: 10mg
Price: $70
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0362706
Product name: 2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 250MG
Price: $441
Updated: 2021/12/16

Matrix Scientific

Product number: 073303
Product name: 2,4-Dichloro-5,6,7,8-tetrahydropyrido-[4,3-d]pyrimidine hydrochloride
Purity: 95+%
Packaging: 250mg
Price: $445
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: D35105
Product name: 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHCl
Purity: 95+%
Packaging: 250mg
Price: $680
Updated: 2021/12/16

Matrix Scientific

Product number: 073303
Product name: 2,4-Dichloro-5,6,7,8-tetrahydropyrido-[4,3-d]pyrimidine hydrochloride
Purity: 95+%
Packaging: 1g
Price: $958
Updated: 2021/12/16

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2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride Chemical Properties,Usage,Production

Uses

2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Hydrochloride acts as a reagent in the preparation of fused aminopyrimidines as glucose uptake inhibitors for treating parasitic and viral infections.

Synthesis

778574-06-4

1208901-69-2

The general procedure for the synthesis of 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride using 6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine as starting material was as follows: compound (C) (35.0 g, 0.106 mol) prepared in step 2 was dissolved in 1,2-dichloroethane (850 mL ), followed by the addition of triethylamine (14.9 mL, 0.107 mol) and 1-chloroethyl chloroformate (34.1 mL, 0.316 mol). The reaction mixture was stirred under heated reflux conditions for 5 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled, washed sequentially with water and saturated saline and the organic phase was dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=3:1). The purified product was dissolved in methanol (850 mL) and heated to reflux stirring for 1 hour. The reaction process was again confirmed by TLC. After completion of the reaction, it was concentrated to dryness under reduced pressure to afford the target compound (D) (23.5 g, 95% yield).

References

[1] Patent: EP1537879, 2005, A1. Location in patent: Page/Page column 61-62
[2] Patent: EP1547616, 2005, A1. Location in patent: Page/Page column 65-66
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 24, p. 10958 - 10971

2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride Suppliers

China 29 India 1 United Kingdom 1 United States 5 Global 36

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1208901-69-2, 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochlorideRelated Search:

2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE HCL

2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine hydrochloride

2,4-Dichloro-5,6,7,8-tetrahyd

1208901-69-2

C7H7Cl2N3ClH

Heterocycle-Pyrimidine series