4'-Azidocytidine

Product Name: 4'-Azidocytidine
CAS No.: 478182-28-4
Chemical Name: 4'-Azidocytidine
Synonyms: R-1479;4'-Azidocytidine;4'-C-azidocytidine;4’-α-Azido-cytidine;R-1479, 10 mM in DMSO;Cytidine, 4'-C-azido-;4'-alpha-Azido-cytidine;R 1479;4'-AZIDOCYTIDINE;R1479;4’-alpha-Azido-cytidine, Balpiravir, R-1479;4-amino-1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
CBNumber: CB82514527
Molecular Formula: C9H12N6O5
Formula Weight: 284.23
MOL File: 478182-28-4.mol

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4'-Azidocytidine Property

storage temp.: Store at -20°C
solubility: DMSO: ≥ 50 mg/mL (175.91 mM)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0362
Product name: R-1479
Purity: 99.98%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001535
Product name: R-1479
Purity: 95.00%
Packaging: 5MG
Price: $505.98
Updated: 2021/12/16

ChemScene

Product number: CS-0362
Product name: R-1479
Purity: 99.98%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611773
Product name: R-1479
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

ChemScene

Product number: CS-0362
Product name: R-1479
Purity: 99.98%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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4'-Azidocytidine Chemical Properties,Usage,Production

Uses

R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM)[1][2][3]. R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

target

HCV

References

[1] Klumpp K, et al. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J Biol Chem. 2006 Feb 17;281(7):3793-9. DOI:10.1074/jbc.M510195200
[2] Smith DB, et al. Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6. DOI:10.1016/j.bmcl.2007.02.004
[3] Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013 May 1;207(9):1442-1450. DOI:10.1093/infdis/jis470

4'-Azidocytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-Azidocytidine Suppliers

China 75 United States 5 Global 80

Chembest Research Laboratories Limited

Tel: +86-21-20908456
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T&W GROUP

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Haoyuan Chemexpress Co., Ltd.

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Nanjing Baifuli Technology Co., Ltd.

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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NINGBO INNO PHARMCHEM CO.,LTD.

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Shanghai YuLue Chemical Co., Ltd.

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View Lastest Price from 4'-Azidocytidine manufacturers

Career Henan Chemical Co

Product: 4'-Azidocytidine 478182-28-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 553
Release date: 2019-09-01

478182-28-4, 4'-AzidocytidineRelated Search:

Cytosine

4'-Azidocytidine

R-1479

4'-C-azidocytidine

4'-alpha-Azido-cytidine

Cytidine, 4'-C-azido-

R 1479;4'-AZIDOCYTIDINE;R1479

4’-alpha-Azido-cytidine, Balpiravir, R-1479

4’-α-Azido-cytidine

4-amino-1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4’-alpha-Azido-cytidine, R-1479,Balpiravir, HCV NS5B polymerase inhibitor, antiviral drug to treat dengue virus infection

R-1479, 10 mM in DMSO

478182-28-4

C9H12N6O5