ChemicalBook > CAS DataBase List > 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

Product Name
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
CAS No.
91526-18-0
Chemical Name
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Synonyms
DMDO-OH;4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one;AZATMint-D;Azilsartan Impurity 55;Azilasartan medoximil(HPLC-98.2%);4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one;1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-
CBNumber
CB82515847
Molecular Formula
C5H6O4
Formula Weight
130.1
MOL File
91526-18-0.mol
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4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Property

Boiling point:
214℃
Density 
1.367
Flash point:
93℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
liquid
pka
14.54±0.10(Predicted)
color 
Pale yellow
InChI
InChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3
InChIKey
JEQSUJXHFAXJOW-UHFFFAOYSA-N
SMILES
O1C(C)=C(CO)OC1=O
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Safety

HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
H939928
Product name
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Packaging
50mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
2H25-1-2V
Product name
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Purity
97%
Packaging
1g
Price
$48
Updated
2021/12/16
Apolloscientific
Product number
OR927927
Product name
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Purity
96%
Packaging
1g
Price
$30
Updated
2021/12/16
Apolloscientific
Product number
OR927927
Product name
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Purity
96%
Packaging
5g
Price
$110
Updated
2021/12/16
SynQuest Laboratories
Product number
2H25-1-2V
Product name
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Purity
97%
Packaging
5G
Price
$176
Updated
2021/12/16
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4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Chemical Properties,Usage,Production

Description

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.

Definition

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl) methylglyoxal chloride, which provides for an alternative approach to introduce the (oxodioxolenyl) methylcarbamate group.

Uses

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.

Preparation

At 20-25°C, 50 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one and 45 g of formic acid were added to 500 mL of acetonitrile. The reaction was cooled to 10-15°C followed by 95 g of triethylamine added. The mixture was heated to 60-65°C and stirred for approximately 5-6 h. The reaction system was subsequently cooled to 15-20°C, filtered, and washed with acetonitrile. Collecting filtrate, and the acetonitrile was removed under vacuum to concentrate the solution. The reaction system was again cooled to 25-30°C, and ethyl acetate and water were added. The mixture was then stirred for approximately 15-20 minutes at 25-30°C. Finally, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one was obtained after further purification.

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Suppliers

BOC Sciences
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View Lastest Price from 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-(hidroximetil)-5-metil-1,3-dioxol-2-ona 91526-18-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-11-19
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Olmesartan Medoxomil Impurity 57 91526-18-0
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-14
Xuchang Hengsheng Pharmaceutical Co., Ltd
Product
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 91526-18-0
Price
US $0.00/Kg
Min. Order
1Kg
Purity
≥99.0%
Supply Ability
10 Tons
Release date
2024-08-07

91526-18-0, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-oneRelated Search:


  • 4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one
  • 1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-
  • 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona
  • 4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one
  • 4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one
  • DMDO-OH
  • 4-Methyl-5-hydroxyMethyl-2-oxo-1,3-dioxol-4-ene
  • AZATMint-D
  • 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona ISO 9001:2015 REACH
  • Azilsartan Impurity 55
  • Azilasartan medoximil(HPLC-98.2%)
  • 4-(hydroxymethyl)-5-methyl-2H-1,3-dioxol-2-one
  • 4- (hydroxymethyl) -5- methyl -[1,3] dioxolane -2- one
  • 4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one
  • 91526-18-0
  • 94526-18-0