4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- Product Name
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- CAS No.
- 91526-18-0
- Chemical Name
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- Synonyms
- DMDO-OH;4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one;AZATMint-D;Azilsartan Impurity 55;Azilasartan medoximil(HPLC-98.2%);4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one;1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-
- CBNumber
- CB82515847
- Molecular Formula
- C5H6O4
- Formula Weight
- 130.1
- MOL File
- 91526-18-0.mol
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Property
- Boiling point:
- 214℃
- Density
- 1.367
- Flash point:
- 93℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- liquid
- pka
- 14.54±0.10(Predicted)
- color
- Pale yellow
- InChI
- InChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3
- InChIKey
- JEQSUJXHFAXJOW-UHFFFAOYSA-N
- SMILES
- O1C(C)=C(CO)OC1=O
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H939928
- Product name
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2H25-1-2V
- Product name
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- OR927927
- Product name
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- Purity
- 96%
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- OR927927
- Product name
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- Purity
- 96%
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 2H25-1-2V
- Product name
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- Purity
- 97%
- Packaging
- 5G
- Price
- $176
- Updated
- 2021/12/16
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Chemical Properties,Usage,Production
Description
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.
Definition
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl) methylglyoxal chloride, which provides for an alternative approach to introduce the (oxodioxolenyl) methylcarbamate group.
Uses
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.
Preparation
At 20-25°C, 50 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one and 45 g of formic acid were added to 500 mL of acetonitrile. The reaction was cooled to 10-15°C followed by 95 g of triethylamine added. The mixture was heated to 60-65°C and stirred for approximately 5-6 h. The reaction system was subsequently cooled to 15-20°C, filtered, and washed with acetonitrile. Collecting filtrate, and the acetonitrile was removed under vacuum to concentrate the solution. The reaction system was again cooled to 25-30°C, and ethyl acetate and water were added. The mixture was then stirred for approximately 15-20 minutes at 25-30°C. Finally, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one was obtained after further purification.
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one manufacturers
- Product
- 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona 91526-18-0
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2021-11-19
- Product
- Olmesartan Medoxomil Impurity 57 91526-18-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-14
- Product
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 91526-18-0
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- ≥99.0%
- Supply Ability
- 10 Tons
- Release date
- 2024-08-07