4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

Product Name: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
CAS No.: 91526-18-0
Chemical Name: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Synonyms: DMDO-OH;4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one;AZATMint-D;Azilsartan Impurity 55;Azilasartan medoximil(HPLC-98.2%);4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one;1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-
CBNumber: CB82515847
Molecular Formula: C5H6O4
Formula Weight: 130.1
MOL File: 91526-18-0.mol

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4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Property

Boiling point:: 214℃
Density: 1.367
Flash point:: 93℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: liquid
pka: 14.54±0.10(Predicted)
color: Pale yellow
InChI: InChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3
InChIKey: JEQSUJXHFAXJOW-UHFFFAOYSA-N
SMILES: O1C(C)=C(CO)OC1=O

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: H939928
Product name: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Packaging: 50mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H25-1-2V
Product name: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Purity: 97%
Packaging: 1g
Price: $48
Updated: 2021/12/16

Apolloscientific

Product number: OR927927
Product name: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Purity: 96%
Packaging: 1g
Price: $30
Updated: 2021/12/16

Apolloscientific

Product number: OR927927
Product name: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Purity: 96%
Packaging: 5g
Price: $110
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H25-1-2V
Product name: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Purity: 97%
Packaging: 5G
Price: $176
Updated: 2021/12/16

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4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Chemical Properties,Usage,Production

Description

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.

Definition

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl) methylglyoxal chloride, which provides for an alternative approach to introduce the (oxodioxolenyl) methylcarbamate group.

Uses

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.

Preparation

At 20-25°C, 50 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one and 45 g of formic acid were added to 500 mL of acetonitrile. The reaction was cooled to 10-15°C followed by 95 g of triethylamine added. The mixture was heated to 60-65°C and stirred for approximately 5-6 h. The reaction system was subsequently cooled to 15-20°C, filtered, and washed with acetonitrile. Collecting filtrate, and the acetonitrile was removed under vacuum to concentrate the solution. The reaction system was again cooled to 25-30°C, and ethyl acetate and water were added. The mixture was then stirred for approximately 15-20 minutes at 25-30°C. Finally, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one was obtained after further purification.

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Suppliers

China 224 India 10 United States 10 Global 244

BOC Sciences

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View Lastest Price from 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona 91526-18-0
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-11-19

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Olmesartan Medoxomil Impurity 57 91526-18-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-14

Xuchang Hengsheng Pharmaceutical Co., Ltd

Product: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 91526-18-0
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: ≥99.0%
Supply Ability: 10 Tons
Release date: 2024-08-07

91526-18-0, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-oneRelated Search:

Azilsartan Azilsartan Impurity 1-((2'-cyanobiphenyl-4-yl)Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylic acid 2-[Bis[(1,1-diMethylethoxy)carbonyl]aMino]-3-nitrobenzoic Acid Methyl Ester BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER Methyl 3-aMino-2-((2'-carbaMoylbiphenyl-4-yl)MethylaMino)benzoate Azilsartan Medoxomil Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid (Z)-Methyl 3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate Azilsartan iMpurity I Methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate

4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one

1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-

4-(hidroximetil)-5-metil-1,3-dioxol-2-ona

4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one

4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one

DMDO-OH

4-Methyl-5-hydroxyMethyl-2-oxo-1,3-dioxol-4-ene

AZATMint-D

4-(hidroximetil)-5-metil-1,3-dioxol-2-ona ISO 9001：2015 REACH

Azilsartan Impurity 55

Azilasartan medoximil(HPLC-98.2%)

4-(hydroxymethyl)-5-methyl-2H-1,3-dioxol-2-one

4- (hydroxymethyl) -5- methyl -[1,3] dioxolane -2- one

4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one

91526-18-0

94526-18-0