3-bromo-1H-pyrazol-5-amine
- Product Name
- 3-bromo-1H-pyrazol-5-amine
- CAS No.
- 950739-21-6
- Chemical Name
- 3-bromo-1H-pyrazol-5-amine
- Synonyms
- 5-broMo-1H-pyrazol-3-aMine;3-BroMo-5-aMinopyrazole;3-Amino-5-bromopyrazole;3-Bromo-5-amine-1H-pyrazol;3-bromo-1H-pyrazol-5-amine;3-bromo-1H-pyrazo1-5-amine;5-Bromo-1H-pyrazol-3-ylamine;1H-Pyrazol-3-amine, 5-bromo-
- CBNumber
- CB82517937
- Molecular Formula
- C3H4BrN3
- Formula Weight
- 161.99
- MOL File
- 950739-21-6.mol
3-bromo-1H-pyrazol-5-amine Property
- Boiling point:
- 384.2±22.0 °C(Predicted)
- Density
- 2.039±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.16±0.10(Predicted)
- form
- solid
- color
- Off-white to yellow
- InChI
- InChI=1S/C3H4BrN3/c4-2-1-3(5)7-6-2/h1H,(H3,5,6,7)
- InChIKey
- VGBYIGUWAWHQOT-UHFFFAOYSA-N
- SMILES
- BrC1NN=C(C=1)N
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- B688080
- Product name
- 3-Bromo-1H-pyrazol-5-amine
- Packaging
- 10g
- Price
- $1470
- Updated
- 2021/12/16
- Product number
- 3H30-9-1N
- Product name
- 3-Amino-5-bromopyrazole
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- J51226
- Product name
- 3-Bromo-1H-pyrazol-5-amine
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3H30-9-1N
- Product name
- 3-Amino-5-bromopyrazole
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 122197
- Product name
- 3-Bromo-5-aminopyrazole
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $182
- Updated
- 2021/12/16
3-bromo-1H-pyrazol-5-amine Chemical Properties,Usage,Production
Uses
3-Bromo-1H-pyrazol-5-amine is used as a reactant in near-IR fluorescence imaging probe that preferentially binds to cannabinoid receptors CB2R over CB1R.
Synthesis
104599-37-3
1203705-55-8
The reduction reaction was carried out by refluxing 3,4-dibromo-5-nitro-1H-pyrazole (69 g) through stannous chloride dihydrate (135 g) in a solvent mixture of ethyl acetate (600 mL) and ethanol (300 mL) at 110 °C for 45 min. Upon completion of the reaction, the yellow homogeneous reaction solution was cooled to room temperature and slowly poured into a vigorously stirred mixture of aqueous sodium bicarbonate (33 g) (200 mL) and ethyl acetate (800 mL). Diatomaceous earth (30 g) was added to the resulting slurry, which was subsequently filtered through a bed of diatomaceous earth. The filter cake was washed with additional ethyl acetate (600 mL). The combined organic phases were washed with brine (200 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give the crude product as an orange oil. The crude product was purified by fast column chromatography (Biotage, Quad 25; eluent: dichloromethane solution in 6% ethanol) to give the final 5-bromo-1H-pyrazol-3-amine as a light beige solid (13.2 g, 32% yield).1H NMR (400 MHz, DMSO-d6) δ: 5.20 (m,3H), 11.60 (br s 1H).
References
[1] Patent: US2013/324547, 2013, A1. Location in patent: Paragraph 0521
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 3, p. 1238 - 1249
3-bromo-1H-pyrazol-5-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-bromo-1H-pyrazol-5-amine manufacturers
- Product
- 3-bromo-1H-pyrazol-5-amine 950739-21-6
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2020-12-11
- Product
- 3-bromo-1H-pyrazol-5-amine 950739-21-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20