ChemicalBook > CAS DataBase List > N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide

N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide

Product Name
N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide
CAS No.
217171-01-2
Chemical Name
N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide
Synonyms
PD 173212;PD173212,PD-173212;PD173212, 10 mM in DMSO;N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide;L-Tyrosinamide, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-
CBNumber
CB82518848
Molecular Formula
C38H53N3O3
Formula Weight
599.85
MOL File
217171-01-2.mol
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N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide Property

Boiling point:
753.4±60.0 °C(Predicted)
Density 
1.053±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: 100 mM; Ethanol: 100 mM
pka
13.83±0.46(Predicted)
form 
Powder
color 
White to off-white
InChIKey
GCDHMGROXQUFNR-HEVIKAOCSA-N
SMILES
O=C([C@@H](NC([C@@H](N(C)CC1=CC=C(C=C1)C(C)(C)C)CC(C)C)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2)NC(C)(C)C
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29447
Product name
PD 173212
Packaging
500μg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
29447
Product name
PD 173212
Packaging
1mg
Price
$60
Updated
2024/03/01
Cayman Chemical
Product number
29447
Product name
PD 173212
Packaging
5mg
Price
$176
Updated
2024/03/01
Tocris
Product number
3552
Product name
PD173212
Purity
≥98%(HPLC)
Packaging
10
Price
$308
Updated
2021/12/16
TRC
Product number
P218365
Product name
PD173212
Packaging
10mg
Price
$345
Updated
2021/12/16
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N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide Chemical Properties,Usage,Production

Description

PD 173212 is an N-type calcium channel blocker (IC50 = 36 nM). It prevents audiogenic seizures in mice when administered at a dose of 30 mg/kg.

Uses

PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.

in vivo

PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1].

References

[1] Hu LY, et al. Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2151-6. DOI:10.1016/s0960-894x(99)00359-5

N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide Suppliers

China 63 United Kingdom 1 United States 9 Global 73
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Shanghai Sphchem Co., Ltd.
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021-56491756 13512199871
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2819742715@qq.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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EMMX Biotechnology LLC
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888-539-0666
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8447
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Shanghai YuanYe Biotechnology Co., Ltd.
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Shanghai Rechem science Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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Sales@ATKchemical.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Hangzhou Peptidego Biotech Co.,Ltd.
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0571-87213919
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Eric@peptidego.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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9729
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217171-01-2, N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamideRelated Search:


  • N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide
  • PD 173212
  • L-Tyrosinamide, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-
  • PD173212,PD-173212
  • PD173212, 10 mM in DMSO
  • 217171-01-2
  • C38H53N3O3