N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea

Product Name: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
CAS No.: 685506-42-7
Chemical Name: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
Synonyms: GSK 264220A;1-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-3-phenylurea;N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea;Urea, N-[2-methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenyl-
CBNumber: CB82518934
Molecular Formula: C17H21N3O4S
Formula Weight: 363.43
MOL File: 685506-42-7.mol

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N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea Property

Density: 1.375±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol
form: Powder
pka: 13.63±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13009
Product name: GSK264220A
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 13009
Product name: GSK264220A
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 13009
Product name: GSK264220A
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 13009
Product name: GSK264220A
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Tocris

Product number: 3752
Product name: GSK264220A
Purity: ≥98%(HPLC)
Packaging: 10
Price: $182
Updated: 2021/12/16

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N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea Chemical Properties,Usage,Production

Uses

GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor, expected to be useful for the treatment of cardiovascular disease.

Biological Activity

GSK264220A is a potent, active site-targeting, covalent inhibitor against endothelial lipase (EL or LIPG; IC50 = 130 nM) and lipoprotein lipase (LPL or LIPD; IC50 = 100 nM). GSK264220A reduces NeuT expression - or CoCl2 treatment-induced intracellular triacylglycerol & lipid droplets (TAG & LD) increase in MCF-7 (16 & 32 nM) and suppresses LPL-depenent melanoma survival (by ~50% at 18.75 μM; WM852, WM1361). When applied in mice in vivo (30 mg/kg ip.), GSK264220A21 enhances lipid nanoparticles-mediated siRNAs delivery & gene-silencing efficacy.

storage

Store at +4°C

N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea Suppliers

China 34 United Kingdom 1 United States 7 Global 42

3B Pharmachem (Wuhan) International Co.,Ltd.

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TargetMol Chemicals Inc.

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ShangHai ChuanQian Chemcial Technique Centre

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MedBioPharmaceutical Technology Inc

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TargetMol Chemicals Inc.

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Suzhou Zhixin Biotechnology Co., Ltd.

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685506-42-7, N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylureaRelated Search:

GSK 264220A

N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea

1-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-3-phenylurea

Urea, N-[2-methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenyl-

685506-42-7