N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

Product Name: N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide
CAS No.: 857290-04-1
Chemical Name: N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide
Synonyms: PF 915275;PF 915275;PF915275;PF-915275, 10 mM in DMSO;PF-915275,PF915275,inhibit,Inhibitor,PF 915275;N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide;N-(6-Aminopyridin-2-yl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide;N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide;N-(6-Aminopyridin-2-yl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide;N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide;[1,1'-Biphenyl]-4-sulfonamide, N-(6-amino-2-pyridinyl)-4'-cyano-
CBNumber: CB82518954
Molecular Formula: C18H14N4O2S
Formula Weight: 350.39
MOL File: 857290-04-1.mol

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N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide Property

Boiling point:: 610.9±65.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble in DMSO
pka: 7.97±0.29(Predicted)
form: Powder
color: White to pink

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0400
Product name: PF-915275
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $89
Updated: 2022/05/15

Sigma-Aldrich

Product number: PZ0400
Product name: PF-915275
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $361
Updated: 2022/05/15

Tocris

Product number: 3291
Product name: PF915275
Purity: ≥98%(HPLC)
Packaging: 10
Price: $181
Updated: 2021/12/16

Tocris

Product number: 3291
Product name: PF915275
Purity: ≥98%(HPLC)
Packaging: 50
Price: $749
Updated: 2021/12/16

Usbiological

Product number: 256220
Product name: PF 915275
Packaging: 10mg
Price: $423
Updated: 2021/12/16

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N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide Chemical Properties,Usage,Production

Biological Activity

PF-915275 is an orally active, potent and selective 11beta-hydroxysteroid dehydrogenase type 1 (11?-HSD1, HSD11B1) inhibitor (human 11?-HSD1 Ki <1 nM; cellular IC50 = 5 nM using human 11?-HSD1-transfected HEK293) with reduced potency toward non-human species (human/monkey/dog hepatocytes EC50 = 20/100/120 nM; mouse 11?-HSD1 Ki = 750 nM, r at hepatoma EC50 = 14 μM). PF-915275 (0.1-3-mg/kg via nasogastric intubations) inhibits prednisone-to-prednisolone conversion in cynomolgus monkeys (by 87% with 3 mg/kg) in vivo and reduces plasma insulin increase following prednisone & resumed feeding (4 hrs post PF-915275) among overnight fasted monkeys.

storage

Store at RT

N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide Suppliers

China 40 United Kingdom 1 United States 10 Global 51

Shanghai SuperLan Chemcial Technique Centre

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MedChemexpress LLC

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Musechem

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857290-04-1, N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamideRelated Search:

N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

PF 915275

N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide

PF 915275;PF915275

[1,1'-Biphenyl]-4-sulfonamide, N-(6-amino-2-pyridinyl)-4'-cyano-

PF-915275,PF915275,inhibit,Inhibitor,PF 915275

N-(6-Aminopyridin-2-yl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

N-(6-Aminopyridin-2-yl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

PF-915275, 10 mM in DMSO

857290-04-1

Potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki=2.3 nM)