ChemicalBook > CAS DataBase List > AC-55541

AC-55541

Product Name
AC-55541
CAS No.
916170-19-9
Chemical Name
AC-55541
Synonyms
AOB2796;CS-1802;CS-2020;AC 55541;AC55541; AC-55541;AC 55541,inhibit,AC-55541,AC55541,Inhibitor,Protease Activated Receptor (PAR),Thrombin receptors;(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;1-Phthalazineacetic acid, α-(benzoylamino)-3,4-dihydro-4-oxo-, (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;N-({N'-[(1E)-1-(3-bromophenyl)ethylidene]hydrazinecarbonyl}(4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide
CBNumber
CB82518974
Molecular Formula
C25H20BrN5O3
Formula Weight
518.36
MOL File
916170-19-9.mol
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AC-55541 Property

Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO
form 
powder
pka
10.99±0.46(Predicted)
color 
White to off-white
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Safety

WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A3609
Product name
AC-55541
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$177
Updated
2022/05/15
Cayman Chemical
Product number
17736
Product name
AC-55541
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17736
Product name
AC-55541
Purity
≥98%
Packaging
5mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
17736
Product name
AC-55541
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
17736
Product name
AC-55541
Purity
≥98%
Packaging
25mg
Price
$479
Updated
2024/03/01
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AC-55541 Chemical Properties,Usage,Production

Uses

AC 55541 is a selective protease-activated receptor 2 agonist.

Definition

ChEBI: AC-55541 is an organic molecular entity.

Biological Activity

ac 55541 is a potent agonist of par2 with pec50 value of 6.7 and functions range from 200 to 1000 nm [1-3].protease-activated receptor 2 (par2) is a member of the large family of 7-transmembrane receptors and plays an important role in modulating inflammatory responses and acting as a sensor for proteolytic enzymes generated during infection [2].ac 55541 is a selective par2 agonist and has no effect on par1. using a cellular proliferation assay (r-sat), it showed that ac 55541 stimulated nih-3t3 cells proliferation by activating par2 and receptor with f240s mutation constitutively active in all functional assays which nearly 30-fold sensitive to ac 55541 than sligrl and 2-furorl ligrlo [1, 2]. when tested with human corneal epithelial (hce) cells, administration of ac 55541 significantly induced the expression of par2 and inhibited acanthamoeba plasminogen activator (apa) [3].in male sprague-dawley rat model with acute thermal nociception and edema in paw induced by sligrl-nh2 or trypsin, intrapaw administration of ac 55541 induced hind paw edema and thermal hyperalgesia at the doses as low as 30 ng and showed dose-dependent pronociceptive effects [1].

storage

Store at -20°C

References

1. gardell, l.r., et al., identification and characterization of novel small-molecule protease-activated receptor 2 agonists. j pharmacol exp ther, 2008. 327(3): p. 799-808.2. ma, j.n. and e.s. burstein, the protease activated receptor 2 (par2) polymorphic variant f240s constitutively activates par2 receptors and potentiates responses to small-molecule par2 agonists. j pharmacol exp ther, 2013. 347(3): p. 697-704.3. tripathi, t., m. abdi, and h. alizadeh, protease-activated receptor 2 (par2) is upregulated by acanthamoeba plasminogen activator (apa) and induces proinflammatory cytokine in human corneal epithelial cells. invest ophthalmol vis sci, 2014. 55(6): p. 3912-21.

AC-55541 Preparation Products And Raw materials

Raw materials

Preparation Products

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916170-19-9, AC-55541Related Search:


  • (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide
  • AC 55541
  • CS-2020
  • CS-1802
  • AC 55541,(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide
  • (E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide
  • AC55541; AC-55541
  • (2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide AC55541
  • AOB2796
  • alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide
  • 1-Phthalazineacetic acid, α-(benzoylamino)-3,4-dihydro-4-oxo-, (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide
  • AC 55541,inhibit,AC-55541,AC55541,Inhibitor,Protease Activated Receptor (PAR),Thrombin receptors
  • (E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazineyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide
  • N-({N'-[(1E)-1-(3-bromophenyl)ethylidene]hydrazinecarbonyl}(4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide
  • 916170-19-9
  • C25H20BrN5O3
  • Inhibitors